性别决定和伴性遗传(英文版).ppt

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1、sexdetermination&sex－linkedinheritanceJiQiuyan&WangDongzhouDec.1st2010sexdetermination&sex－linkedinheritancesex-linkedinheritancesexdeterminationsexdeterminationconceptionmechanismconceptionsexdetermination:Duringembryonicdevelopment,aembryonicgonadwhichstillnod

2、ifferentiation,todeterminetodevelopintotestesorovariesintheprocess.Itistosaydioeciousbiologicalsexdeterminism,anditisresultfromtheinteractionofgenetic,environmentalandphysiologicalfactors.MainsexchromosomesXY▲ZWXOmechanismFourcelllinesinGonad:germcellsteroid-pro

3、ducingcells(male:leydig;female:theca)sertolicells(male:sertoli;female:follicol)relatedcellsninegenestobeconcernedwithsexdifferentiation(Molecularlevel)Sex-determininggeneofsexchromosome:Sex-determiningregionofYchromosome：—SRYSex-determiningregionofXchromosome：—

4、DAX1Sex-determininggeneoneuchromosome:SOX（SOX3、SOX9）AMH(MIS)WT1SF1Dmrt1Wnt4SRY(Sex-determiningregionofYchromosome)1.SRYplaytheon-offaction，andthegeneofmanhavethefunctionoftranscription。SRYcanrestrainthedevelopmentofMullerianductbydominantthesecretionofsomething;

5、italsocanproducemalestructures.2.IffemalebeshortofSRY,theDSSofXchromosomewilltranscription,sotopromotethedevelopmentofovary.DAX1(Dosagesensitivesex-reversal-adrenalhypoplasiacongenital-criticalregionoftheXchromosomegene1)♦DAX1stemfromtwogeneticlocisofXchromosom

6、ewhichnameisDSSandAHC;♦DAX1proteinisaffectedbyretinoicacidreceptornegativeregulatoroftranscriptionfactors,thereisthefunctionofovary-mediated.SOX(Sry-typeHMGbox)SOX9(Sry-typeHMGbox9)♦SOX9havetherulebothonSkeletalDevelopmentandsexdetermination♦SOX9Initiallyexpress

7、edinbothmaleandfemalegenitalridge,whensryexpressed,itwillexpressinthemalegenitalridge,andthenCausepodocytedevelopment♦Sox9havethesamefunctionofSRY,andifSrygenedeletion,SOX9willInducemaledifferentiationtoensurenormaldevelopmentofmaleSOX3(Sry-typeHMGbox3)SOX3isthe

8、onlygenewhichlieinXchromosome.ThisgeneassociatedwiththeSrygene,SOX3andSrygenesmaybeallele.itcanencodeSry-bindingproteininmalesexembryos,andplaytheruleinembryoniccentr