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1、EurRadiol(2007)17:2898–2907DOI10.1007/s00330-007-0660-8MOLECULARIMAGINGOlivierHaugerUSPIO-enhancedMRimagingofmacrophageNicolasGrenierColetteDeminèreinfiltrationinnativeandtransplantedkidneys:CatherineLasseurYahsouDelmasinitialresultsinhumansPierreMer
2、villeChristianCombeAbstractThepurposeofthisstudysignallossonT2*-weightedimages.Received:16August2006Revised:22March2007wastoevaluatethedetectionandIntheremainingeightpatients,with2Accepted:3April2007characterizationofmacrophageinfil-<5macrophages/mm,
3、therewasnoPublishedonline:22May2007trationinnativeandtransplantedcorticalsignalloss.However,inthree#Springer-Verlag2007kidneysusingultrasmallsuperpara-ofthese,presentingwithischemicmagneticironoxideparticlesacutetubularnecrosis,astrong(42±O.Hauger(*)
4、.N.Grenier(USPIO).Among21patientsinitially18%)signaldropwasfoundintheServiced’ImagerieDiagnostiqueetThérapeutiquedel’Adulte,Groupeenrolled,12scheduledforrenalbiop-medullaexclusively.USPIO-en-HospitalierPellegrin,syforacuteorrapidlyprogressivehancedMR
5、imagingcandemonstratePlaceAmélieRaba-Léon,renalfailure(n=7)orrenalgraftinfiltrationofthekidneysbymacro-33076BordeauxCedex,Francerejection(n=5)completedthestudy.phagesbothinnativeandtransplantede-mail:olivier.hauger@chu-bordeaux.frThreemagneticresonan
6、ce(MR)ses-kidneysandmayhelptodifferentiateTel.:+33-5-56795605Fax:+33-5-56796014sionswereperformedwitha1.5-Tbetweenkidneydiseases.system,before,immediatelyafterandO.Hauger.N.Grenier72hafteri.v.injectionofUSPIOatKeywordsUSPIO.Nativekidney.Laboratoired’
7、ImagerieMoléculaireetdosesof1.7–2.6mgofiron/kg.SignalTransplantedkidneyFonctionnelle,ERTCNRS/UniversitéVictorSegalenBordeaux2,intensitychangewasevaluatedvi-Bordeaux,Francesuallyandcalculatedbasedonaregionofinterest(ROI)positionedonC.Deminèrethekidney
8、compartments.Histologi-Serviced’Anatomo-pathologie,GroupeHospitalierPellegrin,calexaminationshowedcorticalmac-Bordeaux,Francerophageinfiltrationinfourpatients2(>5macrophages/mm),twoinnativeC.Lasseur.Y.Delmas.P.Merville.kidneys(proliferativeextracapil
