急性脑梗死患者血液炎症因子水平与颈动脉粥样硬化斑块的关系-论文.pdf

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1、·222·StrokeandNervousDiseases，Aug2014，Vo1．21，No．4急性脑梗死患者血液炎症因子水平与颈动脉粥样硬化斑块的关系桂千程庆璋【摘要】目的探讨急性脑梗死患者血液炎症因子水平与颈动脉粥样硬化斑块的关系。方法将146例急性脑梗死患者依颈动脉超声检查分为3组，即无斑块组(38例)，稳定斑块组(48例)及不稳定斑块组(60例)，其中I、Ⅱ、Ⅲ级斑块各为29、41、38例，检测各组患者发病3d内的血浆肿瘤坏死因子一a(TNF-a)、白介素6(IL-6)水平。结果稳定斑块组及不稳定斑块组血浆TNF-~、IL-6水平明显高于无斑块组，不稳定斑块组明显高于稳定斑块组，

2、且随着斑块严重程度的增加，其血浆TNF-a、IL-6水平也明显增高(P均<0．05)。结论血浆TNF_a、IL-6水平可以反映急性脑梗死患者颈动脉粥样硬化的严重程度。【关键词】脑梗死颈动脉粥样硬化肿瘤坏死因子一a白介素6【中图分类号】R743．3【文献标识码】A【文章编号】1007—0478(2014)04—0222—03【D0I】10．3969／j．issrL1007—0478．2014．04．008Relationshipbetweenlevelsofbloodinflammatoryfactorsandcarotidatherosclerosisplaqueinpatientswit

3、hacutecerebralinfarctionGui@an，ChengQingzhang．DepartmentofNeurology，SuzhouMunicipalHos—pital，Jiangsu215002[Abstract]ObjectiveToexploretherelationshipbetweenlevelsofbloodinflammatoryfactorsandca—rotidatherosclerosisplaqueinpatientswithacutecerebra1infarction(ACI)．MethodsAhundredandforty-sixACIpatie

4、ntsweredividedintothreesubgroupsaccordingtotheresultsofcarotidultrasoundexamination：nonplaquegroup(38cases)，stableplaquegroup(48cases)andunstableplaquegroup(60cases)．Andtherewere29cases，41casesand38caseswithplaquegradeI，IIandmrespectively．Thelevelsofplasmatumornecro—sisfactor-a(TNF-a)andinterleuki

5、n6(IL-6)weredetectedinthreedaysandtheresultswerecomparedamongthesegroups．ResultsThelevelsofplasmaTNF-aandIL-6instableplaquegroupandunstableplaquegroupweresignificantlyhigherthanthoseinnonplaquegroup，andwhichinunstableplaquegroupweresignificantlyhigherthaninstableplaquegroup，Alongwiththeincreaseofp

6、laqueseverity，thelevelsofplasmaTNF-aandID6wereremarkablyincreased．thedifferenceswerestatisticallysignificant(allP<0．05)．ConclusionsThelevelsofplasmaTNF_aandIL-6arerelatedtOtheseverityofcarotidatherosclerosisinACIpatients．[Keywords]CerebralinfarctionCarotidatherosclerosisTumornecrosisfactor-aInterl

7、eukin6颈动脉粥样硬化斑块是引起脑梗死的重要原因子水平与颈动脉粥样硬化斑块的关系。之一，动脉斑块的破裂导致暴露脂质核心，激活凝1对象与方法血系统，血栓形成，栓子脱落导致动脉一动脉栓塞l_1]。炎症因子在动脉粥样硬化疾病的发生发展中发挥重1．1对象收集2013年3月一2013年12月在本院要作用，炎症反应参与动脉粥样硬化的形成过程_2]。神经内科住院的病程<3d的急性脑梗死患者146血浆肿瘤坏死因子一d(TNF-a)和