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《奥曲肽与垂体后叶素治疗肝硬化上消化道出血的疗效比较-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、-短篇论著·奥曲肽与垂体后叶素治疗肝硬化上消化道出血的疗效比较梁川(成都市青白江区人民医院消化科,四川成都610300)【摘要】目的对比分析奥曲肽和垂体后叶素在救治肝硬化上消化道出血的疗效。方法将本院2011年3月~2013年10月收治的64例肝硬化上消化道出血患者随机分为两组,各32例,两组均予以常规治疗,观察组在常规治疗基础上联合奥曲肽治疗,对照组在常规治疗基础上联合垂体后叶素治疗,观察对比两组的临床疗效。结果显示观察组总有效率(9O.6%)及不良反应率(12.5%)与对照组总有效率(68.8%)及不良反应发生率(43.8%),差异有统计学意义(P2、物治疗肝硬化上消化道出血较好选择,但奥曲肽临床效果更加显著,不良反应少,安全性好。【关键词】奥曲肽;垂体后叶素:肝硬化上消化道出血【中图分类号】R573.2【文献标识码JB【文章编号l1674—9308(2014)01—0015-02DOI:10.3969/3.ISSN.1674—9308.20]4.0】.009EficacycomparisonofoctreotideandpituitrininthetreatmentofuppergastrointeslinalhemorrhageinhepaticcirrhosisLIANGChuan.DepartmentofGastroenterolo3、gy,QingbaijiangPeople'sHospital,Chengdu610300,China【Abstract】0bjectiveTocontrastiveanalyzetheeficacyofoctreotideandpituitrinintreatmentofuppergastrointestinalhemorrhageinhepaticcirrhosis.MethodsChosing64hepaticcirrhosispatientswithuppergastrointestinalhemorhageinourhospitalanddividingthemintotwogrou4、ps,eachgroup(32cases),allofthegroupreceivedconventionaltherapy.Theobservationgroupreceivedthetreatmentofoctreotideplusconventionaltherapy.Thecontrolgroupreceivedthetreatmentofpituitrinplusconventionaltherapy.Thecurativeefectwerecompared.ResultsT0ta1efectiverate(90.6%)andtheincidenceofadversereaction5、s(12.5%)intheobservationgroup.T0talefectiverate(68.8%)andtheincidenceofadversereactions(43.8%)inthecontrolgroup,thediferencebetweentwogroupswasstatisticallysignificant(P<0.05).ConclusionOctreotideandpituitrinintreatmentofuppergastrointestinalhemorrhageinhepaticcirhosishavegoodeficacy,buttheefectofoc6、treotideismoreobviousandsafety,andhasfewadversereactions.【KeywordslOctreotide;Pituitrin;Hepaticcirhosis;Uppergastrointestinalhemorrhage上消化道出血约占内科住院患者的3%,其中肝硬化门脉输血指征安排急诊输血等必要治疗。高压所致胃食管静脉曲张『生上消化道出血患者占~U20%,常1.2.1观察组在常规治疗基础上联合奥曲肽(成都力思常伴有失血性周围循环衰竭,病死率高,是消化系统常见急症,特制药股份有限公司生产)治疗,给予0.1mg的奥曲肽缓需要积极治疗]。本文旨在对比7、分析奥曲肽和垂体后叶素慢静脉注射后以25~50g,}l持续静脉泵入,持续48~72h。在救治肝硬化上消化道出血的疗效差异,现报告如下。1.2.2对照组在常规治疗基础上联合垂体后叶素(安徽宏业药业有限公司生产)治疗,给予6U的垂体后叶素缓1资料与方法慢静脉注射后以6~12U/h持续静脉泵入,持续48—72h。1.1一般资料本组患者64例,男39例,女25例;年1.3疗效评价标准J,显效:用药48h后
2、物治疗肝硬化上消化道出血较好选择,但奥曲肽临床效果更加显著,不良反应少,安全性好。【关键词】奥曲肽;垂体后叶素:肝硬化上消化道出血【中图分类号】R573.2【文献标识码JB【文章编号l1674—9308(2014)01—0015-02DOI:10.3969/3.ISSN.1674—9308.20]4.0】.009EficacycomparisonofoctreotideandpituitrininthetreatmentofuppergastrointeslinalhemorrhageinhepaticcirrhosisLIANGChuan.DepartmentofGastroenterolo
3、gy,QingbaijiangPeople'sHospital,Chengdu610300,China【Abstract】0bjectiveTocontrastiveanalyzetheeficacyofoctreotideandpituitrinintreatmentofuppergastrointestinalhemorrhageinhepaticcirrhosis.MethodsChosing64hepaticcirrhosispatientswithuppergastrointestinalhemorhageinourhospitalanddividingthemintotwogrou
4、ps,eachgroup(32cases),allofthegroupreceivedconventionaltherapy.Theobservationgroupreceivedthetreatmentofoctreotideplusconventionaltherapy.Thecontrolgroupreceivedthetreatmentofpituitrinplusconventionaltherapy.Thecurativeefectwerecompared.ResultsT0ta1efectiverate(90.6%)andtheincidenceofadversereaction
5、s(12.5%)intheobservationgroup.T0talefectiverate(68.8%)andtheincidenceofadversereactions(43.8%)inthecontrolgroup,thediferencebetweentwogroupswasstatisticallysignificant(P<0.05).ConclusionOctreotideandpituitrinintreatmentofuppergastrointestinalhemorrhageinhepaticcirhosishavegoodeficacy,buttheefectofoc
6、treotideismoreobviousandsafety,andhasfewadversereactions.【KeywordslOctreotide;Pituitrin;Hepaticcirhosis;Uppergastrointestinalhemorrhage上消化道出血约占内科住院患者的3%,其中肝硬化门脉输血指征安排急诊输血等必要治疗。高压所致胃食管静脉曲张『生上消化道出血患者占~U20%,常1.2.1观察组在常规治疗基础上联合奥曲肽(成都力思常伴有失血性周围循环衰竭,病死率高,是消化系统常见急症,特制药股份有限公司生产)治疗,给予0.1mg的奥曲肽缓需要积极治疗]。本文旨在对比
7、分析奥曲肽和垂体后叶素慢静脉注射后以25~50g,}l持续静脉泵入,持续48~72h。在救治肝硬化上消化道出血的疗效差异,现报告如下。1.2.2对照组在常规治疗基础上联合垂体后叶素(安徽宏业药业有限公司生产)治疗,给予6U的垂体后叶素缓1资料与方法慢静脉注射后以6~12U/h持续静脉泵入,持续48—72h。1.1一般资料本组患者64例,男39例,女25例;年1.3疗效评价标准J,显效:用药48h后
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