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时间:2020-05-15
《脐血干细胞移植治疗对失代偿期肝硬化患者细胞因子水平的影响及其临床意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第44卷第3期第294页华中科技大学学报(医学版)VoL44No.3P.2942015年6月ActaMedUnivSciTechnolHuazhongJun.2015脐血干细胞移植治疗对失代偿期肝硬化患者细胞因子水平的影响及其临床意义*江必武,贾学平,吴玉芳,李轶西,胡伟,刘嵩,时昭红△武汉市中西医结合医院消化内科,武汉430022摘要:目的探讨失代偿期肝硬化患者经脐血干细胞移植治疗后血清中细胞因子水平的变化及其临床意义。方法选取5O例失代偿期肝硬化患者,经肝动脉灌注进行脐血干细胞移植治疗,采用ELISA方法检测术前及术后第8、l6、24周血清中肿瘤坏死因子一a(TNF—)、
2、自细胞介素一6(IL-6)、成纤维细胞生长因子一B(FGF-13)水平及肝纤维化指标的变化。结果患者在脐血干细胞移植治疗后第8周就出现肝功能好转并持续改善,第16、24周较术前明显改善,差异均有统计学意义(均P<0.05);治疗后第16、24周患者血清中TNF-a、IL-6、FGF—G水平均较术前明显下降,差异均有统计学意义(均P<0.05);术后第24周肝纤维化指标亦有明显改善(P3、失代偿期肝硬化;肿瘤坏死因子一a;白细胞介素一6;成纤维细胞生长因子一8;肝纤维化指标中图分类号:R575.2DOI:10.3870/j.issn.1672—0741.2015.03.011ChangesofCytokinesinPatientswithDecompensatedLiverCirrhosisafterUmbilicalCordBloodStemCellTransplantatiOnandtheClinicalSignificanceJiangBiwu,JiaXueping,WuYufangetalDepartmentofGastroenterology,Wuh4、anIntegratedChineseandWesternMedicineHospital,Wuhan430022,ChinaAbstractObjectiveToinvestigatethechangesofcytokinesintheserumofpatientswithdecompensatedlivercirrhosisafterumbilicalcordbloodstemcelltransDlantationandtheirclinicalsignificance.MethodsAtotalof50patientswithdecom—pensatedlivercir5、rhosiswererecruitedinthestudyandtreatedwithumhilica1cordbloodstemcel1transD1antationbvhepaticarterialinfusion.The1evelsofTNF一,IL一6,FGF-Bandthe1iverfibrosisindexesintheserumweredetectedbymeansofELISAbeforeand8,16,24weeksaftertransD1antationandthechangesoftheseindexeswereobserved.ResultsTheli6、verfunctionwasimproved8weeksafterumhilica1cordbloodstemcel1transD1antationandwascontinuouslyimproved.Therewassignificantdifferenceintheliverfunctionindexesbetweenbeforeand16,24weeksaftertransplantation(P7、nd24weekswithsignificantdifferenceobservedwhencomparedwiththosebeforetransp1antation(P<:O.05).Moreover,the1iverfibrosisindexeswerealsoimprovedsignifi—cantlyat24weeks(P
3、失代偿期肝硬化;肿瘤坏死因子一a;白细胞介素一6;成纤维细胞生长因子一8;肝纤维化指标中图分类号:R575.2DOI:10.3870/j.issn.1672—0741.2015.03.011ChangesofCytokinesinPatientswithDecompensatedLiverCirrhosisafterUmbilicalCordBloodStemCellTransplantatiOnandtheClinicalSignificanceJiangBiwu,JiaXueping,WuYufangetalDepartmentofGastroenterology,Wuh
4、anIntegratedChineseandWesternMedicineHospital,Wuhan430022,ChinaAbstractObjectiveToinvestigatethechangesofcytokinesintheserumofpatientswithdecompensatedlivercirrhosisafterumbilicalcordbloodstemcelltransDlantationandtheirclinicalsignificance.MethodsAtotalof50patientswithdecom—pensatedlivercir
5、rhosiswererecruitedinthestudyandtreatedwithumhilica1cordbloodstemcel1transD1antationbvhepaticarterialinfusion.The1evelsofTNF一,IL一6,FGF-Bandthe1iverfibrosisindexesintheserumweredetectedbymeansofELISAbeforeand8,16,24weeksaftertransD1antationandthechangesoftheseindexeswereobserved.ResultsTheli
6、verfunctionwasimproved8weeksafterumhilica1cordbloodstemcel1transD1antationandwascontinuouslyimproved.Therewassignificantdifferenceintheliverfunctionindexesbetweenbeforeand16,24weeksaftertransplantation(P7、nd24weekswithsignificantdifferenceobservedwhencomparedwiththosebeforetransp1antation(P<:O.05).Moreover,the1iverfibrosisindexeswerealsoimprovedsignifi—cantlyat24weeks(P
7、nd24weekswithsignificantdifferenceobservedwhencomparedwiththosebeforetransp1antation(P<:O.05).Moreover,the1iverfibrosisindexeswerealsoimprovedsignifi—cantlyat24weeks(P
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