男性甲亢患者血清β2-MG、TGAb、TMAb测定的临床意义.pdf

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1、医学检验与临床2011年第22卷第3期MedicalLaboratoryScienceandClinics．2011，Vo122，N0．3·21·doi：10．3969／i．issn．1673—5013．2011．03．OO9男性甲亢患者血清』32一MG、TGAb、TMAb测定的临床意义卢晓宋庆璋(山东省莱芜市人民医院检验科，山东莱芜271100)【摘要】目的为了探讨男性甲亢患者药物治疗后缓解较慢的原因。方法通过用放免法测定患者血清82一MG，TGMb、TMAb的含量变化，将172例男性甲亢患者根据治疗过程分为三组，即初发组(B组，68)，未缓解组(C组，55)，缓解组(D组，49)；61

2、名正常人作为对照组(A组)。结果甲亢B纽与c组血清一MG，I=I3，FI'4水平明显高于A组(P<0．O1)，而TGAb，TMAb的阳性率明显下降(P≤0．01)，B组与C组m，FT4与一MG呈明显JY_相关，而缓解组一MG，FT3，FF4与A纽相比，差别无显著性(P>0．05)，D组与c组相比，TGAb，TMAb阳性率差别无显著性(P>0．05)。D组22．69％的患者血清B2一MG仍明显增高，24．3％的患者TGAb，TMAb仍持续阳性。结论血清一MG、TGAb，TMAb可作为男性甲亢免疫缓解指标，其检测值可以观察疗效，指导治疗。大约28％左右男性甲亢患者缓解较慢，可能是由于患者血清一

3、MG持续增高。TGAl，TM持续阳性造成的。【关键词】男性；甲亢；微球蛋白；甲状腺球蛋白抗体；甲状腺微粒体抗体；放射免疫分析Clinicalsignificanceofserum一MG，TGAbandTMAbdetectioninillaleHyperthyroidismPatientsLuXiao，SongQingzhang(DepartmentofClinicalI．aberatory，ThePeople’sHospitalofLaiwu，Laiwu271100China)【Abstract]ObjectiveToStudythecauseforslowrecoveryinmalehy

4、perthyroidismpatientsaftertreatedwithATD．MethodsThechangesofscrota一MG，TGAbandTMAbWeremeasuredbyRIA．Atotalof172malehyperthyroidismpatientswerediVidedinto3groupby．theirdiferenttherapeuticefects：untreatedpatients(groupB，n=68)，treatedbutunrelievedpatients(groupC，n=55)，treatedandrecoveredpatients(group

5、D，n=49)，and61normalpersonserving8scontrols(groupA)．ResultsTheresansindicatedthatthelevels0fseYtlntlG2一MG，FIBandFT4weresignificantlyhigheringroupBandCthanthoseingroupA(P<0．01)，butthepositiveratesofTGAbandTMAbwereno—tablylowerthanthoseingroupA(P<0．01)．TherewasapositivecorrelationbetweenFIBorFF4and一M

6、GrespectivelyingroupBandC．TherewasnoSignineantdiferencein一MG，F13andFY4betweengroupDanidA(P>0．05)．AndtherewasnodiferenceintheposJ—fiveratesofTGAbandTMAbbetweengroupDandC(P>0．05)．Theseruiu一MGwasstillhigherin22．69％patientsandthepositiveratesofTGAbandTMAbwerealsohigherin24．3％patients．ConclusionThesere

7、sultssuggestThat一MG，TGAbandTMAbcouldactasserummal'kersofimalunologiealremissionformalehyperthyroidismpatientsandthedeterminationof一MG，TGAbandTMAbcouldbebenifiealtomonitoringtherapeuticefect．Thecausefors]owrecover