痰热清注射液辅助治疗儿童肺炎支原体肺炎的疗效及对血清炎症因子水平的影响.pdf

《痰热清注射液辅助治疗儿童肺炎支原体肺炎的疗效及对血清炎症因子水平的影响.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、Jour实nal用ofa譬in．ic要alM医ed药icin鸯ein志Practice2015年’第⋯19卷⋯第。11期⋯·182·痰热清注射液辅助治疗儿童肺炎支原体肺炎的疗效及对血清炎症因子水平的影响周卫忠(湖北省鄂州市中医医院药剂科，湖北鄂州，436000)摘要：目的探讨痰热清注射液辅助治疗儿童肺炎支原体肺炎(MPP)的疗效及对血清炎症因子水平的影响。方法98例MPP患儿随机分为对照组和观察组，各49例，2组均给予阿奇霉素序贯治疗，即阿奇霉素静脉滴注治疗5d后，口服阿奇霉素颗粒，治疗3d，停药4d后再口服4d。观察组在此基础上加用痰热清注射液静脉滴注，连用1

2、周。结果治疗1周后，观察组总有效率9183％，高于对照组总有效率67．35％(P<0．01)；观察组咳嗽、发热及肺部罗音消失时间均短于对照组(P<0．01)；2组治疗后c反应蛋白(CRP)、白细胞介素一6(IL-6)、白细胞介素一1O(IL，1O)及肿瘤坏死因子一n(僻a)水平均较治疗前下降(P<0．O1)，且观察组低于对照组，差异有统计学意义(P<0．05或P<0．01)。结论在常规治疗基础上加用痰热清注射液，可提高临床疗效，加快症状缓解，有效降低血清炎症因子水平。关键词：肺炎支原体肺炎；儿童；阿奇霉素；痰热清注射液；炎症因子中图分类号：R563．1文献标志码

3、：A文章编号：1672—2353(2015)11．182—03DOI：10．7619~cmp．201511068EfficacyofadjuvanttherapyoftanreqinginjectionintreatmentofchildrenwithmycoplasmapneumoniaepneumoniaanditsinfluenceonseruminflammatorycytokinelevelsZHOUWeizhong(DepartmentofPharmacy，EzlumHospitalofTraditionalChineseMedicine，EOU，H

4、ube／，436000)ABSTRACr：ObjectiveToexploretheefficacyofadjuvanttherapyoftanreqinginjectionintreatmentofchildrenwithmycoplasmapneumoniaepneumonia(M[E)P)anditsinfluenceonseruminflammatorycytokineslevels．MethodsAtotalof98childrenwithPwererandomlydividedintoobservationgroupandcontrolgroup，4

5、3casesineachgroup．Azithromycinsequentialtherapywasgiventobothgroups．After5daysofazithromycinintravenousinjection，oralazithromycinpar-tideswasgivenfor3days．Thenazithromycinwassuspendedfor4daysfollowedbyoraladminis—trationforanother4days．Basedonthis，childrenintheobservationgroupreceive

6、dintravenoustan—reqinginjectioncontinouslyforoneweek．ResultsThetotaleffectiveratewas91．83％intheob．servationgroup，whichwassignificantlyhigherthan67．35％inthecontrolgroup(P<0．O1)．Thecoughtime，fevertimeandpulmonaryralesdisappearancetimeintheobservationgroupwereshort-edthanthoseintheeontr

7、olgroup(P<0．O1)．Aftertreatment，theC-reactiveprotein(CRP)，in—terleukin(IL)一6，IL一10andtumornecrosisfactor—a(TNF—a)1evelsdecreasedsignificantlythanthosebeforetreatment(P<0．01)，and1evelsofindexesmentionedaboveintheobservationgroupweresignificantlybetterthanthoseinthecontrolgroup(P<0．05or

8、P<0．01)．Conc