吗啡成瘾及癫痫造模对ICR小鼠学习记忆能力的相关性研究.pdf

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1、重庆医科大学学报2012年第37卷第l1期(JournalofChongqingMedicalUniversity2012．VOI．37NO．11】一957一DOI：10．39696．issn．0253-3626．2012．11．007吗啡成瘾及癫痫造模对ICR小鼠学习记忆能力的相关性研究林梅，黄昶荃z，李永红。，彭小东，林红。，杨波。(1．四川中医药高等专科学校临床医学系内科教研室，绵阳621000；2．绵阳市第三人民医院老年康复科，绵阳621000；3．成都信息工程学院电子工程学院生物医学工程教研室，成都610225；4．川北医学院附属医院肿瘤科，南充637000)【摘要】目的：观察

2、吗啡成瘾及癫痫对ICR小鼠的空间学习记忆能力的影响是否具有相关性。方法：将40只小鼠随机分成吗啡成瘾继发癫痫组、吗啡成瘾组、癫痫组和空白对照组，每组10只。用连续注射吗啡建立吗啡成瘾模型，用匹罗卡品(Pilo—carpine，PLO)建立癫痫模型。用水迷宫实验检测各组小鼠的记忆能力。结果：吗啡成瘾继发癫痫小鼠与癫痫小鼠水迷宫逃避潜伏期时间相对比明显延长(P<0．05)。结论：吗啡成瘾与癫痫对ICR小鼠的学习记忆能力损害具有协同作用。【关键词】成瘾；癫痫；水迷宫；学习记忆【中国图书分类法分类号】R749【文献标志码】A【收稿日期】2012—07—13CorrelationbetweenMo

3、rphineaddiction，epilepsymodelandlearningandmemorizingofICRmiceLINMei1,HUANGChangquan2,LIYonghongz。PENGXiaodong~，LINHong3，YANGBo3(．TeachingandResearchSectionofInternalMedicine，SchoolofClinicalMedicine，SichuanCollegeofTraditionalChineseMedicine；2．DepartmentofGeriatricRehabilitation，theThirdPeople’S

4、HospitalofMianyang；3．TeachingandResearchSectionofBiomedicalEngineering，CollegeofElectronicEngineering，ChengduUniversityofInformationTechnology；4．DepartmentofOncology，theAffiliatedHospital，NorthSichuanMedicalCollege)【Abstract]Objective：TocreateMorphineaddictionmodelbyconditionedplacepreferencefirs

5、tlyandthentocreateepilepsymodelonthebasisofMorphineaddiction．finallytostudywhetherMorphineaddictionandepilepsyexerteffectsonspatiallearningandmemorizingofinstituteofcancerresearch(ICR)micefrombehavioralbywatermaze．Methods：Totally40ICRmicehavingexcellentperformancebyearlyplatformofnaturalpreferenc

6、eandtrainingofwatermazewereselected．AllthesemicewereequallydividedintoMorphineaddictioncomplicatedwithepilepsygroup，Morphineaddictiongroup，epilepsygroupandcontrolgroup(n=10)．SevendayscontinuousinjectionofMorphinewasusedtocreateMorphineaddictionmodelwhilePiloearpinewasinjectedtocreateepilepsymode1

7、．Watermazetestwasperformedtoobservethelearningandmemorizingofmice．Results：WatermazeescapelatencywaslongerinMorphineaddictioncomplicatedepilepsymicethaninepilepsymice．Conclusion：Morphineadditionandepilepsyexensynergisti