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1、Thl7在乙型慢加急性肝衰竭中的表达及意义•210冲国卫生检验杂志2014年1月第24卷第2期ChinJHealthLabTec,Jan2014,Vol24,No2•临床检验•李华建廊坊市人民医院检验科，河北丿邮坊065000IL-17变化和意义。方法流式细胞检摘要：目的探讨乙肝慢加急性肝衰竭(HBV—ACLF)患者外周血中的Thl7、42例慢性乙型肝炎患者，37例乙肝肝硬化失代偿期患者，27例健康者的外周测术检测51例乙肝慢加急性肝衰竭患者、AST)及HBVDNA载量相关性。血Thl7,酶联免疫法检测其I
2、LT7,同时分析Thl7与谷丙转氨酶和谷草转氨酶(ALT,结果HBV-ACLF患者组的Thl7及IL-17较其他三组显著增高(PV0.05)oCHB患者组和HBV—LC患者组外周血中Thl7及IL-17较健康组显著增高(P<0.05),而CHB患者组和HBV-LC患者组之间Thl7及11_一17差别无统计学P<0.05)、AST(r=0.597,P<0.05)呈正相关；与意义(P>0.05)oHBV-ACLF患者外周血Thl7与ALT(r=0.603,HBVDNA水平无相关(r=0.356,P>0.05)。
3、结论Thl7及其分泌的IL-17可能促进了CHB患者的肝脏损伤及HBV—ACLF的发生及发展，冇望成为HBV-ACLF患者肝脏损伤程度的免疫学指标。关键词:Thl7;IL-17;乙型肝炎病毒;慢加急性肝衰竭中图分类号：R575.3文献标识码：A文章编号：1004-8685(2014)02-210-03ExpressionandsigrdficanceofThl7inHBV—associatedacute—on—chronicliverfailurepatientsLIHua—jianDepartmentof
4、CIinicalLaboratory,LangfangPeople'sHospital,Langfang065000,ChinaAbstract：ObjectiveTodiscussthechangesandclinicalsigrdficanceofThl7andlL—：17inHBV—associatedacute—on—ThelevlesofThl7andlL—17weremeasuredin51HBV—ACLFpatients,42chronichepatitischronicliverfa
5、ilure(HBV—ACLF)patientsbyobservingtheexpressionfrequencyofThl7andlL—17inperipheralbloodofdifferentpopulation.MethodsB(CHB)patients,37decompensatedlivercirrhosispatients(HBV—LC)and27heathycases(HC)respectivelybyflowcytom-etryandELISA.Thecorrelationbetweenth
6、eexpressionfrequencyofThl7andALT,ASTandtheserumHBVDNAIoadwerealsoanalyzedatthsametime.ResultsThl7andlL—17inperipheralbloodofHBV—ACLFpatientswerehigherthanthoseinotherthreegroups(P<0.05)；Thl7andlL—17inperipheralbloodofCHBandHBV—LCwerehigherthanthoseinHC(P<0
7、.05).Thl7andlL—lTinperipheralbloodofCHBandHBV-LChadnosignificantstatisticaldifference(P>0.05).Thl7inperipheralbloodofHBV—ACLFpatientsshowedpositivecorrelationwithALTIevel(r=0.603,P<0.05)andASTIevel(r=0.0・597,P<0.05),whileitshowednocorrelationwithHBVDNAIeve
8、l(r=0.356,P>0.05).ConclusiondeterminationoftheliverdamagedegreeinHBV—ACLFpatients.Keywords：Thl7；IL—17；HepatitisBvirus；AcuteonchronicliverfailureThl7cellsandIL—17maybeinvolvedintheoccurrenceanddevelopmentofHBV
