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1、#390#辽宁中医杂志2010年第37卷第3期慢性乙型肝炎中医证型与生化及氧化损伤指标的相关性研究1122王振常,毛德文,黄彬,李益忠(11广西中医学院第一附属医院,广西南宁530023;21广西中医学院附属瑞康医院,广西南宁530011)摘要:目的:探讨慢乙肝患者生化、氧化损伤指标与中医证型的相关性。方法:对381例慢乙肝患者进行辨证分型,以同期健康体检正常者30例为正常对照组,检测血清生化及脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)。结果:¹AST、ALT、GGT、NO、M
2、DA在湿热中阻、瘀血阻络、肝肾阴虚证中较其它证型显著升高(P<0101或P<0105);ºGLO、LPO、aPOA-1/aPOB在瘀血阻络、肝肾阴虚证中高于其它证型而ALB、A/G比值较低(P<0101);»TBA、CHE、aPOA-1、aPOB在瘀血阻络、肝肾阴虚、脾肾阳虚证中明显低(P<0101)。结论:生化及氧化损伤指标可为慢乙肝中医辨证的客观化提供依据。关键词:慢乙肝;生化;氧化损伤指标;中医辨证分型中图分类号:R512162文献标识码:B文章编号:1000-1719(2010)03-0390-03Correl
3、ativeStudyonTCMSyndromeofChronicHepatitisBandIndexesofSerumBiochemistryandOxidativeStress1122WANGZhen-chang,MAODe-wen,HUANGBin,LIYi-zhong(11TheFirstHospitalAffiliatedtoGuangxiTraditionalChineseMedicalCollege,Nanning530023,Guangxi,China;21RuikangHospitalAffiliate
4、dtoGuangxiTraditionalChineseMedicalCollege,Nanning530011,Guangxi,China)Abstract:Objective:ToexplorethecorrelationbetweendifferentsyndrometypesofTCMandindexesofserumbiochemistryandoxidativestressinchronichepatitisB(CHB).Methods:381patientsofCHBwereclassifiedaswel
5、lasdiagnosedwithbloodserumbiochemistry、LPO、SOD、MDA、NO,andcomparedwith30caseshealthcontrolgroup.Results:¹ComparisionamongthedifferentsyndrometypesrevealedthatAST、ALT、GGT、NO、MDAweresignificantlyraisedindamp-heatobstractingthecenter,staticbloodobstructingthenetwork
6、vesselsandliver-kidneyyindeficiency(P<0101orP<0105);ºGLO、LPO、aPOA-I/aPOBweremarkedlyelevatedandmeanwhileALB、A/Gactivitydecreasedinstaticbloodobstructingthenetworkvesselsandliv-er-kidneyyindeficiency(P<0101);»ComparisionamongthedifferentsyndrometypesrevealedthatT
7、BA、CHE、aPOA-I、aPOBweremarkedlydecreasedinstaticbloodobstructingthenetworkvessels,liver-kidneyyindeficiencyandspleen-kidneyyangdeficiency(P<0101).Conclusions:bloodserumbiochemistryandoxidativestresscouldserveasobjectiveindexeforsyn-drometypingofCHB.Keywords:CHB;b
8、iochemistry;oxidativestressindex;syndrometypeofTCM慢乙肝发病机理十分复杂,在病程的不同阶段其医院住院及门诊381例患者。其中男286例,女95病机既有一定的区别,又往往互有兼夹。中医对慢乙例;年龄最小18岁,最大60岁,平均(45186?11115)肝辨证分型的认识,是以中医理论为
