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1、最新ImmuneactivationandImmunopathologyoftheHIVinfection：免疫激活和HIV感染的免疫病理学-药学医学精品资料1981-1997-2007:AIDSandImmuneDeficiencies:The(only?)ComplicationoftheHIVinfection,occurringdespitestrongimmuneresponsestoHIVImmuneReconstitutionwithARVBAutranEACS09RéponsesImmunesCell
2、ulesCD4/mm3ChargeVIH200SIDAInfectionsOpportunistesARV1997–2006:LimitationsofARV:PartialrestorationofImmunitytoHIV=>Concepts:« auto-vaccination »bytreatmentinterruption(STI)Primo-infectionJLisziewiczetal.….E.Rosenbergetal.,1989,2000CTLCD4helpvirusInfectionChroni
3、que:GOrtizetal.,G.Carcelainetal.BHirscheletal.…..1989….2002HIVInfection,ImmuneActivationandCD4celldepletionImmuneresponsesImmuneActivationCD4countsHIVload200CD4DeficiencynegativelycorrelatestoImmuneactivationdespiteinductionofpowerfulimmuneresponsesagainstHIVBA
4、utranEACS09WhereisImmuneactivationcomingfrom?T-cellactivationandCD4countHunt,JID2008N=30HIV+withVL<75c/mLAntigensandCytokines=>HIVreplicatesInlymphoïdtissueswhereActivationtakesplaceBAutran/03HIVrequiresimmuneactivationtoreplicateinactivatedCD4TcellsIsthisnew?N
5、o!In1983FBarré-Sinoussietal.discovered LAV/HIVinalymphnode1yearbeforeallothergroupsthatlookedforHIVinthebloodScience,May1983,220,368HIV-relatedapoptosisofthegutmucosalepitheliainducesMicrobialtranslocationThuselicitingsystemicimmuneactivationJM.Brenchley,….AT.H
6、aase,andDC.DouekNatMed2006BAutran/06SystemicLPSfromtranslocatedBacteriacorrelateswithdiseaseprogressionSystemicLPSbindsMonocyticreceptors(CD14)andelicitsreleaseofpro-inflammatorycytokinesWhat’snew?ChronicInflammation/activationplaysakeyroleinimmunopathologyofHI
7、Vtat,AppayVetal,JPathol08Inflammation/activationchroniqueetimmunopathologieduVIHfromAppayVetal,JPathol08SecretionofPro-inflammatoryCytokinesIL-1b,IL-6,TNF-a,….ChimiokinesMCP-1,CX3CL1,RANTES,….Inflammation-relatedDisordersAtherosclerosisOsteoporosisNeurocognitiv
8、eDegeneration=inflamm-ageing?HowcanHIVinduceatherosclerosis? ThroughInflammationandactivationofmacrophagesBAutranEACS09etal.Univariate&multivariatemodelsassessingtheassociat
