中性粒细胞：免疫

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1、免疫血液学•先天性免疫33炎性白细胞粘附级联位点LFA1-CAM1VLA4-VCAM1Qtd

2、57-integrin-MADCAM1SelectmsPSGLlVLA4Selectssignalling;ChemukinesSRCkir&s^sP0KVAV1.VAV2,VAV3MAOICAM1PECAMIiCD^5JAMSESAMIGAMIPECAM1?Activation^rarellularandTransre[lularrrm^igrarior^rdotheliaLcMsrncrrtrancP/aETubrsiteofinflammationLe

3、yetNatMed20073炎性白细胞粘附级联位点CourtesyofDr.D.Vestweber,Munster3人中性粒细胞抗原(HNA)EndothelHLAP70-95(?)PECAM-1ICD16NA1fNA2,SHCD11b/CD18MartJAM-CCD177JAM-C介导的不同细胞间的级联反应leterophitfc/interactionPlateletsMac-1Sar?tosoef或JExpMed2002Sac-rtset电Blood2004DendriticCellsNeutrophilsKisseletaJfTransfus

4、ion2006LargeretaiTATVB2007immeasGtiuiiet凯JLenkBto/2009homophflicSantosoera/.JBC2005m+aOrlovaeta(,JExpMed2007人中性粒细胞抗原(HNA)PhenotypHNALocalisationFrequencyWhitesFrequencyAsians*NA11aFcyRlllb57-62%88-91%NA21bFeyRilllb£18-89%51-54%SH1cFcyRlllb5%<1%HNA-1null0.15%<1%NB12aCD17719-99%9

5、8%5b3anotknown59-96%?Mart4aCD11b99%>99%Ond5aCD11aS6-92%81%*Chinese,Japanese,Koreans,orTaiwaneseBuxeta/,VoxSang2008FcyRIIIb(CD16b)上的HNA-1D2ig^163N170eeeGs於2A06II」nePBlwrcssaAAAVAla78AspSHGPIanchorIInimnnnnnnffuuuuuuuuuuuuuuu•pointmutation。oligosaccharide嗜中性白细胞抗体的临床影响■非溶血性输血反应发热■

6、新生儿同种免疫性嗜中性白血球减少症■自身免疫嗜中性白血球减少症■骨髓移植后嗜中性白血球减少症9嗜中性白细胞抗体的实验室诊断■粒细胞免疫荧光试验(GIFT)■粒细胞凝集试验(GAT)■淋巴细胞免疫荧光试验(LIFT)■单克隆抗体固定粒细胞抗原法(MAIGA)9嗜中性粒细胞同种抗体foundincurlaboratory(n=31)NA110NA28SH0ND16NB145b1Mart2Ond0HNA-1aHNA-1bHNA-1cHNA-1HNA-2aHNA-3aHNA-4aHNA-5a・75%■25%粒细胞免疫荧光试验(GIFT)粒细胞免疫荧光试验(G

7、IFT)VerheugtetBrJHaematol1977粒细胞免疫荧光试验(GIFT)粒细胞凝集试验(GAT)粒细胞凝集试验(GAT)15151515GAT=0(InkubationmitAB-Plasma)GAT=8015(InkubationmitAnti-HNA-3a)1515淋巴细胞免疫荧光试验(LIFT),llllllllllllllOllllll

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10、jkIllillllblllilltlll

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12、hII-PhotomultiplierfLymphozyt血清学模式GIFTGATLIFTHLANA2Auto-AbnegativeReact

13、ions0-4:HLA免疫法存在的问题GIFTGATLIFT##HLA??NA2#