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1、fungalbiology115(2011)1008e1018journalhomepage:www.elsevier.com/locate/funbioEvolutionofFungalPathogensinDomesticEnvironments?a,ba,cCeneGOSTINCAR*,MartinGRUBE,NinaGUNDE-CIMERMANaCentreofExcellenceforIntegratedApproachesinChemistryandBiologyofProtein
2、s(CIPKeBiP),Jamova39,SI-1000Ljubljana,SloveniabInstituteofPlantSciences,Holteigasse6,8010Graz,AustriacUniversityofLjubljana,BiotechnicalFaculty,DepartmentofBiology,Vecnapot111,SI-1000Ljubljana,SloveniaarticleinfoabstractArticlehistory:Specificindoore
3、nvironmentsselectforcertainstress-tolerantfungiandcandrivetheirReceived20October2010evolutiontowardsacquiringmedicallyimportanttraits.Herewereviewthecurrentknowl-Receivedinrevisedformedgeinthisareaofresearch,focussingontheso-calledblackyeasts.Manyoft
4、hesemelan-7March2011isedstress-tolerantorganismsoriginateinunusualecologicalnichesinnature,andtheyAccepted8March2011haveanumberofpreadaptationsthatmakethemparticularlysuitedforgrowthonhu-Availableonline15March2011man-madesurfacesandsubstrates.Several
5、pathogenicspecieshavebeenisolatedrecentlyCorrespondingEditor:SybrendeHoogfromvariousdomestichabitats.Wearguethatinadditiontoenrichingforepotentiallyepathogenicspecies,theselectionpressureandstressactingonmicroorganismsinindoorKeywords:environmentsare
6、drivingtheirevolutiontowardsacquiringthemissingvirulencefactorsBlackfungiandfurtherenhancingtheirstresstoleranceandpathogenicpotential.Someofthepolyex-Domesticenvironmenttremotolerantfungiareparticularlyproblematic:theycangrowatelevatedtemperatures,E
7、volutionandsotheyhaveahigherpotentialtocolonisewarm-bloodedorganisms.Asseveralspe-Pathogenciesofblackfungiarealreadyimplicatedinhealthproblemsofvariouskinds,theirselec-Polyextremophilictionandpossibleevolutioninhumanenvironmentsareofconcern.Polyextre
8、motolerantª2011BritishMycologicalSociety.PublishedbyElsevierLtd.Allrightsreserved.Introductioncaninfluenceourinteractionswiththebacteriainaunpredict-ableandpossiblydangerousways(Baquero2009).Thisproba-Therecentyearshavewitnessedalarmingnewsrelatingtob
