儿科学

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1、DevelopmentoftheHematopoieticSystem&theIntroductionofAnemiaThedepartmentofPediatric,Hematology/Oncology,Dr.JieYu,MD.AssociateProfessorContentsDevelopmentofhematopoieticsystemHematopoieticorgansHematopoieticbloodcellsCharacteristicofcellcountsandhemoglobinRBCandHblevelHemoglobi

2、nWBC/Platelet/BloodvolumeAnemiaDevelopmentofHematopoieticSystemintheembryoandfetus,constantchangescharacterizeallphasesofhematopoiesis.DevelopmentofHematopoieticOrgansFetalhematopoiesisMesoblasticHematopoiesisHepaticHematopoiesisMyeloidHematopoiesisHematopoiesisafterbirthSITES

3、TIMEPRODUCMeasoblastichematopoisisYolkSac10-14thday3-4wk:primitiveblasts10-12wk:ceasedErythroidHepatichematopoiesisLiver6-8wk:appear12-16wk:active6mo:diminish/stopatbirthErythroidMyeloidhematopoiesisBonemarrow4mo:start6mo:increase/steadyafterbirth:theonlyErythroidNeutrophilsMa

4、crophagesTable1.FetalHematopoiesisDevelopmentofHematopoieticOrgansFetalhematopoiesisHematopoiesisafterbirthBonemarrowhematopoiesisExtrmedullaryhematopoiesisDevelopmentofHematopoieticOrgansHematopoiesisafterbirthBonemarrowhematopoiesisAllbloodcellsareproducedinthemarrowafter2nd

5、trimesterNewbornandearlyinfancy:redmarrow5-7yr:yellowmarrowExtrmedullaryhematopoiesisDevelopmentofHematopoieticOrgansHematopoiesisafterbirthBonemarrowhematopoiesisExtramedullaryhematopoiesisIndiseasesstatus:redcellproductionhematopoietictissue.bloodproductionexpandstoreplace

6、fattymarrow.bloodcellsproductionextendstoextramedullarysites(liverandspleen).DevelopmentoftheHematopoieticBloodCellsPluripotentStemCells:whicharecapableofbothself-renewalandofclonalmaturationintoallbloodcelllineages.Progenitorcellsdifferentiateundertheinfluenceofhematopoieticg

7、rowthfactorsTable2.TheDevelopmentofBloodCellsPROGENITORCYTOKINESPRODUCCFU-GMG-CSFNUTROPHILCFU-MegTPOPLTCFU-EBFU-EEPORBCFig1.HematopoisisBloodCellCountsandHemoglobinFig2.PeripheralBloodCellsRBCandHbLevelAtBirth:RBC:5-7x1012/LHb:150to230g/L.Postnatalfall/physiologyanemiaInfancy

8、Preschoolage:RBC:4x1012/LHb:110g/L7-12yr:adultlevelRBCandHble