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1、111111111111111111111111111111111111111111111111111111111111111111111111111US007135195B2(12)UnitedStatesPatent(10)PatentNo.:US7,135,195B2Holladayetal.(45)DateofPatent:Nov.14,2006(54)TREATMENTOFHUMANSWITHA61P15/02(2006.01)COLLOIDALSILVERCOMPOSITIONA61P17/00(2006.01)A61P31/00(2006.01)(75)Inventors
2、:RobertJ.Holladay,Logan,UT(US);A61P31/02(2006.01)HerbertChristensen,Alpine,UT(US);A61P31/04(2006.01)WilliamD.Moeller,Alpine,UT(US)A61P31/10(2006.01)(52)U.S.Cl.424/618;424/405;424/489;(73)Assignee:AmericanSilver,LLC,Alpine,UT424/490;424/616;514/849;514/858;514/894;(US)514/895;514/924;514/931;514/
3、932;514/934;514/951(*)Notice:Subjecttoanydisclaimer,thetennofthis(58)FieldofClassificationSearch424/618,patentisextendedoradjustedunder35424/405,489,490,616;514/849,858,894,U.S.c.154(b)by409days.514/895,924,931,932,934,951Seeapplicationfileforcompletesearchhistory.(21)Appl.No.:10/641,938(56)Refe
4、rencesCited(22)Filed:Aug.15,2003U.S.PATENTDOCUMENTS(65)PriorPublicationData6,214,299B1*4/2001Holladayetal.422/186.21US2005/0061678AlMar.24,20056,743,348B1*6/2004Holladayetal.205/3416,890,953B1*5/2005Arata514/495RelatedU.S.ApplicationData6,939,568B1*9/2005Burrelletal.424/6182002/0051823Al*5/2002Y
5、anetal.424/618(63)Continuation-in-partofapplicationNo.09/946,834,2003/0185889Al*10/2003Yanetal.424/484filedonSep.4,2001,nowPat.No.6,743,348,whichisacontinuationofapplicationNo.09/323,310,filed*citedbyexamineronJun.1,1999,nowPat.No.6,214,299.PrimaryExaminer-JohnPak(60)ProvisionalapplicationNo.60/
6、475,657,filedonJun.(74)Attorney,Agent,orFirm-Liner,Yankelevitz,Sunshine3,2003.&RegenstreifLLP(51)Int.Cl.(57)ABSTRACTA61K33/38(2006.01)A61K33/40(2006.01)A61K9/10(2006.01)Wediscloseacolorlesscompositioncomprisingsilverpar•A61K9/14(2006.01)ticlesandwater,whereinsaidparticlescompriseaninteriorA01N25
7、/12(2006.01)ofelementalsilverandanexteriorofionicsilveroxide,A01N25/26(2006.01)whereinthesilverparticlesarepresentinthewateratalevelA01N59/16(2006.01)ofabout5-40ppm,andwhereinthecompositionmanifestsA01N59/00(2006.01)signific
