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1、NIHPublicAccessAuthorManuscriptCell.Authormanuscript;availableinPMC2015December04.NIH-PAAuthorManuscriptPublishedinfinaleditedformas:NIH-PAAuthorManuscriptNIH-PAAuthorManuscriptCell.2014December4;159(6):1433–1446.doi:10.1016/j.cell.2014.11.022.Aconstantsizeextensiondrivesbacterialcellsizehomeostasis
2、ManuelCampos1,2,6,IvanV.Surovtsev1,2,6,SetsuKato3,6,AhmadPaintdakhi1,2,BrunoBeltran1,2,3,5,SarahE.Ebmeier1,3,andChristineJacobs-Wagner1,2,3,4,1MicrobialSciencesInstitute,YaleUniversity2HowardHughesMedicalInstitute,YaleUniversity3DepartmentofMolecular,CellularandDevelopmentalBiology,YaleUniversity4De
3、partmentofMicrobialPathogenesis,YaleMedicalSchoolAbstractCellsizecontrolisanintrinsicfeatureofthecellcycle.Inbacteria,cellgrowthanddivisionarethoughttobecoupledthroughacellsizethreshold.Here,weprovidedirectexperimentalevidencedisprovingthecriticalsizeparadigm.Instead,weshowthroughsingle-cellmicrosco
4、pyandmodelingthattheevolutionarilydistantbacteriaEscherichiacoliandCaulobactercrescentusachievecellsizehomeostasisbygrowingonaveragethesameamountbetweendivisions,irrespectiveofcelllengthatbirth.Thissimplemechanismprovidesaremarkablyrobustcellsizecontrolwithouttheneedofbeingprecise,abatingsizedeviati
5、onsexponentiallywithinafewgenerations.Thissizehomeostasismechanismisbroadlyapplicableforsymmetricandasymmetricdivisionsaswellasfordifferentgrowthrates.Furthermore,ourdatasuggestthatconstantsizeextensionisimplementedatorclosetodivision.Altogether,ourfindingsprovidefundamentallydistinctgoverningprinci
6、plesforcellsizeandcellcyclecontrolinbacteria.IntroductionCellsizecontrol,auniversalpropertyofallorganisms,reflectsthebalancebetweengrowthanddivision.Mechanismsmustbeinplacetoensurethatcellsnarrowlydistributearounda©2014ElsevierInc.Allrightsreserved.Contactinformation:christine.jacobs-wagner@yale.edu
7、,tel:+1-203-737-7219,fax:+1-203-737-6715.5Currentaddress:DepartmentofMathematics,LouisianaStateUniversity,BatonRouge,LA70803,USA.6EqualcontributionSupplementalinformationTheSIincludes:microfluidicdevi
