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1、Mutation-specificandcommonphosphotyrosinesignaturesofKRASG12DandG13Dalleles1,234,53,4,53,6RaihaTahir,SantoshRenuse,SavitaUdainiya,AnilK.Madugundu,JevonA.Cutler,RajaSekhar372,32,32,3,5,8,Nirujogi,ChanHyunNa,YaoyuXu,XinyanWu,AkhileshPandey1Biochemistry,CellularandMolecu
2、larBiologyGraduateProgram,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USA2DepartmentofBiologicalChemistry,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USA3McKusick-NathansInstituteofGeneticMedicine,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USA
3、4InstituteofBioinformatics,InternationalTechnologyPark,Bangalore,560066India5ManipalAcademyofHigherEducation(MAHE),Manipal576104,Karnataka,India6Pre-DoctoralTrainingPrograminHumanGenetics,McKusick-NathansInstituteofGeneticMedicine,JohnsHopkinsUniversitySchoolofMedicin
4、e,Baltimore,MD,USA7DepartmentofNeurology,InstituteofCellEngineering,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USA8DepartmentsofPathologyandOncology,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USATABLEOFCONTENTSSupplementalFigure1.Deeperproteomeprofil
5、ingofSW48KRASmutantsknockincells.SupplementalFigure2.MutantKRAS-inducedsignaturesinthetotalproteome.SupplementalFigure3.Full-lengthblots/gelscorrespondingtowesternblotsreportedforthisstudy.SupplementalTableS1.AlistofproteinsidentifiedintheglobalproteomeanalysisSupplem
6、entalTableS2.AlistofphosphotyrosinesitesidentifiedinthisstudySupplementalTable2A.AlistofphosphotyrosinepeptidesquantifiedinthisstudySupplementalTable2B.Alistof812phosphotyrosinepeptidesquantifiedbyPyQuantSupplementalTable2C.Alistof308phosphotyrosinepeptidesquantifiedi
7、nall3replicatesfortheG12DcellsSupplementalTable2D.Alistof308phosphotyrosinepeptidesquantifiedinall3replicatesfortheG13DcellsS-1AB1,086pTyrsites(676proteins)SILACQuantification1952,0325,925(PyQuant)812pTyrsitesquantified(523proteins)Quantifiedinall3replicatesHammondeta
8、l.2015G12D/ParentalG13D/ParentalCurrentstudy308pTyrsites280pTyrsites(222proteins)(213proteins)CSupplementalFigure1.Deeperpro
