the optimization of prolonged release - revista farmacia延长释放药学杂志的优化

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1、299FARMACIA,2008,Vol.LVI,3THEOPTIMIZATIONOFPROLONGEDRELEASEOFMATRIXTABLETSWITHFELODIPINER.I.IOVANOV*,I.TOMUTA,S.E.LEUCUTADepartmentofPharmaceuticalTechnologyandBiopharmaceutics,FacultyofPharmacy,“IuliuHatieganu”University,400023,Cluj-Napoca,ROMANIA*correspondin

2、gauthor:iovanovraresiuliu@yahoo.comAbstractTheobjectiveofthisworkwastoprepareandoptimizesomeprolongedreleasematrixtypetabletswithfelodipinebasedonKollidonSR,inordertoobtainsimilarreleaseprofileswiththeoriginalproduct.Inthisregardafullexperimentaldesignwith2fact

3、orsand3variableswasusedinordertoobservetheinfluenceoftheformulationvariablesonthecharacteristicsofthetablets.Thestudiedvariableswhere:percentofKollidonSRinthetabletanddiferentfillers.Thetabletswherecharacterizedfromthepointofviewofthepharmaceuticalproperties(me

4、chanicalstrength,friabilityandinvitrodissolutionbehavior).TheresultsshowedthatthepercentofKollidonSRinthetabletshasthebiggesteffectonthereleaseoffelodipine.Theoptimumformulageneratedfromtheexperimentaldatawassimilarwiththeoriginalproduct.RezumatObiectivulaceste

5、ilucrăriafostobţinereaşioptimizareaunorpreparatefarmaceuticesolidecucedareprelungitădetipmatriţapebazădeKollidonSRcufelodipinapentruaobţineoformularesimilarăcaprofildedizolvarecupreparatuloriginal.Înacestscopafostdezvoltatunplanexperimentalcompletcu2factorişitr

6、eivariabile.FactoriistudiaţiaufostprocentuldeKollidonSRdincomprimateşiexcipienţiidiluanţifolosiţi.Comprimateleaufostcaracterizatedinpunctdevederealrezistenteimecanice,friabilităţiişiadizolvăriiinvitro.RezultatelearatăcăprocentuldeKollidonSRdinformulareareceamai

7、mareinfluenţăasupravitezeidecedareafelodipinei.Formulareaoptimizatăpreparatăs-adoveditafisimilarăcuceaaprodusuluioriginal.·felodipine·optimization·prolongedreleaseINTRODUCTIONInthelastdecadethenumberofprolongedreleasepharmaceuticalformshasgreatlyincreasedduetot

8、heiradvantages.Theuseofthistypeofmedicationcandecreasetheincidenceofadverseeffectsduetohigherplasmalevelconcentrationsorlackofeffectinthecaseoflowplasma299FARMACIA,2008,Vol.