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1、SUPPLEMENTARYMATERIALAmygdalaabnormalitiesinfirst-degreerelativesofindividualswithschizophreniaunmaskedbybenzodiazepinechallengeDanielH.Wolf,MD,PhD1,TheodoreD.Satterthwaite,MD,MA1,JamesLoughead,PhD1,AmyPinkham,PhD5,EveOverton,BA1,MarkA.Elliott,PhD2,GershamW
2、.Dent,PhD4,MarkA.Smith,MD4,RubenC.Gur,PhD,1,2,3RaquelE.Gur,MD,PhD1,21DepartmentofPsychiatry,UniversityofPennsylvania,PhiladelphiaPA19104,USA2DepartmentofRadiology,UniversityofPennsylvania,PhiladelphiaPA19104,USA3PhiladelphiaVeteransAdministrationMedicalCent
3、er,PhiladelphiaPA19104,USA4AstraZenecaPharmaceuticalsLP,WilmingtonDE19850,USA5DepartmentofPsychology,SouthernMethodistUniversity,DallasTX75275,USAContentsofSupplementaryMaterials:SupplementaryMethodsDetailsonparticipantassessment,imageacquisition,imageproce
4、ssingandimageanalysis.SupplementaryTableS1Behavioralperformance:accuracyandreactiontime.SupplementaryTableS2Significantclustersfromvoxelwiseanalysisofemotionidentificationandmemorytasks.SupplementaryFig.S1Illustrationofacquiredbrainvolumeandregionsofinteres
5、t.SupplementaryFig.S2Illustrationoftaskactivation(vs.fixationbaseline)foremotionidentificationandmemorytasks.SupplementaryFig.S3Illustrationofmemorytaskperformancerelativetoexpectedchanceperformancelevels.SupplementaryFig.S4Illustrationofinversecorrelationb
6、etweenageandemotionidentificationperformance.SupplementaryFig.S5Illustrationofcorrelationbetweendrug-inducedreductioninhippocampalactivationanddrug-inducedreductionsinmemoryperformance.SupplementaryFig.S6Wholebrainglobalperfusionresults.SupplementaryReferen
7、ces12SupplementarymethodsSubjectassessmentTheclinicalevaluationincludedtheDiagnosticInterviewforGeneticStudies(DIGS)(Nurnbergeretal.1994)andFamilyInterviewforGeneticsStudies(FIGS)(Maxwell1992).SchizotypywasassessedwiththeStructuredInterviewforSchizotypy(SIS
8、)(Kendleretal.1989)includedintheDIGS;totalSISscoreswerecalculatedasthesumofglobalitems(SISscoreswereunavailablefor1familymember).AnxietywasassessedusingtheStateTraitAnxietyInventory(STAI)(Spielbergeret
