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1、抗氧化治疗对2型糖尿病合并急性脑梗死患者RBP4及糖脂代谢的影响【摘耍】目的:探讨抗氧化治疗对2型糖尿病合并急性脑梗死患者血清视黄醇结合蛋白4(RBP4)及糖脂代谢的影响。方法:选取2013年6月-2015年6月在临沂市河东区人民医院住院的2型糖尿病合并急性脑梗死患者110例,将患者随机分为治疗组56例和对照组54例。患者均行生活方式干预,给予降糖、调脂、降压、抗血小板凝聚、改善循环药物治疗。在此基础上治疗组将a-硫辛酸注射液600mg加入250mL0.9%氯化钠溶液中静脉滴注,1次/d,连用3周,对照组予以
2、维生素C治疗。观察治疗前后两组的RBP4、胱抑素C(Cys-C)、半胱氨酸(Iley).高敏C反应蛋白(hs-CRP)、血糖(FPG、2hPG、HbAlc)、血脂(TG、TC、LDL-C、FFA)、B细胞功能(HOMA-IR、HOMA-3)>血压、体重指数、心电图、肝肾功能、电解质以及NTHSS评分等方面的变化,并记录药物不良反应。结果:两组治疗后的RBP4、Cys-C、Hey、hs-CRP水平、FPG、2hPG>HbAlc、HOMA-IR、TG、TC、LDL-C、FFA较治疗前均下降,IIOMA-0均升高,
3、其中治疗组变化更明显,治疗组下降幅度与对照组比较差异均有统计学意义(卩〈0.01);两组治疗后的NIHSS评分较治疗前均下降,治疗组下降更显著,差异有统计学意义(卩〈0.01);两组未发现明显不良反应。结论:抗氧化剂硫辛酸治疗2型糖尿病合并急性脑樓死,可明显降低患者RBP4和血糖、血脂水平,改善胰岛0细胞功能,并可降低NIIISS评分。EffectofAntioxidantTherapyontheLevelsofRetinolBinding卩rotein4andGlucose一lipidmetabolismi
4、nPatientswithType2DiabeticComplicatedwithAcuteCerebralInfarction/ZHAOLiang,ZHAOJian-kang.//MedicalInnovationofChina,2015,12(34):001-004【Abstract】Objective:Toresearchtheefficacyofantioxidanttherapyonthelevelsofretinolbindingprotein4andglucose-lipidmetabolism
5、inpatientswithtype2diabeticcomplicated(T2DM)withacutecerebralinfarction(ACI).Method:110patientswithT2DMcomplicatedwithacutecerebralinfarctionwererandomizedintotwogroups.Patientsweretreatedwithlifestyleintervention,bloodsugar,lipid,bloodpressure,antiplatelet
6、aggregationandimprovedcirculationdrugs.Onthisbasis,56casesofthetreatmentgroupweregivenalpha-lipoicacid600mgand250mL0.9%sodiumchloridesolution,1time/d,3weeks;thecontrolgroupwastreatedwithvitaminC.The1evelsofRBP4,Cys~C,Hey,hs-CRP,bloodglucose(FPG>2hPG>HbAlc),
7、bloodlipid,bloodpressureandbodyweightweremeasuredandthescoreofNTHSSwasevaluatedbeforeandafterthetreatment・Result:Afteronecourseoftreatment,thelevelsofRBP4,Cys-C,Iley,hs-CRP,FPG,2hPG,HbAlc,TG,TC,HOMA-TRweredecreasedoftwogroups,thetreatmentgroupwasbetterthant
8、hecontrolgroup,thedifferenceswerestatisticallysignificant(P[Keywords]Alpha-lipoicacid;Type2diabetesmellitus;Cerebralinfarction;Retinolbindingprotein4First-author?saddress:ThePeople'sHospitalofHedongDis