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1、牛磺酸对大鼠肢体缺血再灌注后肝脏损伤的保护效应论文王银环，董淑云，张娜，赵利军，李宏杰，孔小燕，刘丽华，张连元【关键词】再灌注损伤；肝功能；四肢；牛磺酸Protectiveeffectoftaurineagainstliverinjuryafterlimbischemiareperfusioninrats【Abstract】AIM:Toobservetheliverinjuryandinvestigatetheprotectiveeffectoftaurineontheliverfunctionafterlimbischemiar
2、eperfusion.METHODS:ThirtyDA,AST,ALTandSODinplasmaeasuredafter4hlimbischemiaand4hreperfusionineachgroup.XOD,MDA,ROS,MPOand［Ca2+］inthelivertissuesandGSHPX,［Ca2+］inthelivermitochondriaol/Lvs(1.27±0.21)nmol/L］,ALT［(78.40±6.45)nkat/Lvs(20.50±3.70)nkat/L］,.freelaincreased,b
3、utSOD［(1.30±0.15)μkat/Lvs(1.80±0.16)μkat/L］reduced,XOD［(104.69±12.34)μkat/kgvs(59.01±10.50)μkat/kg］,MDA［(2.66±0.08)nmol/Lvs(1.29±0.14)nmol/L］,ROS［(771.65±100.69)μkat/Lvs(606.45±52.01)μkat/L］,MPO(0.47±0.04vs0.28±0.06),［Ca2+］［(0.248±0.050)mmol/Lvs(0.123±0.014)mmol/L］int
4、helivertissuesincreased,GSHPx［(20.34±4.67)nkat/Lvs(31.17±11.50)nkat/L］inthelivermitochondriamol/Lvs(0.14±0.03)mmol/L］increased;InTRgroupparedol/L］,ALT［(64.40±9.05)nkat/L］,AST［(38.70±8.10)nkat/L］aofTRgroupincreased;thevaluesofXOD［(94.19±13.50)μkat/L］,MDA［(1.67±0.12)nmo
5、l/L］,ROS［(710.81±55.34)μkat/L］,MPO(0.36±0.04),［Ca2+］［(0.192±0.426)mmol/L］inthelivertissuesdecreased,thevaluesofGSHPx［(22.50±3.17)nkat/L］inthelivermitochondriaofTRgroupobviouslyincreased,but［Ca2+］［(0.31±0.06)mmol/L］reduced.CONCLUSION:Thetaurinecouldprotecttheliverfunct
6、ionofratsafterlimbischemiareperfusion.【Keyities;taurine【摘要】目的：观察大鼠肢体缺血再灌注后肝脏的损伤性变化，以及牛磺酸对肝脏损伤性变化的保护效应，探讨牛磺酸对大鼠肢体缺血再灌注后肝脏功能保护作用的可能机制.方法：实验用DA,AST,ALT和SOD的变化；观察肝组织XOD,MDA,ROS,MPO和Ca2+的变化；观察肝线粒体GSHPX和Ca2+的变化.结果：单纯肢体缺血再灌注组大鼠血浆中LDH［(190.16±13.36)μkat/L］,XOD［(758.82±151.53)
7、nkat/L］,MDA［(5.19±0.67)nmol/L］,ALT［(78.40±6.45)nkat/L］,AST［(47.70±4.47)nkat/L］等较正常对照组血浆中LDH［(122.39±14.87)μkat/L］,XOD［(543.61±43.51)μkat/kg］,MDA［(1.27±0.21)nmol/L］,ALT［(20.50±3.70)nkat/L］,AST［(25.25±2.98)nkat/L］明显增加，而SOD［（1.30±0.15)μkat/L］较对照组(1.80±0.16)μkat/L明显降低；单纯肢
8、体缺血再灌注组大鼠肝组织XOD［(104.69±12.34)μkat/Kg］,MDA［(2.66±0.08)nmol/L］,ROS［(771.65±100.69)μkat/L］,MPO(0.47±0.04),［Ca2+］［(0.248±0.050)
