资源描述:
《血必净注射液对重症肺炎患者的疗效及其对细胞免疫及炎症因》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、血必净注射液对重症肺炎患者的疗效及其对细胞免疫及炎症因子的影响陈山(海南省农垦总医院呼吸内科,海南海口570311)【摘要】目的:研究血必净注射液对重症肺炎患者的临床疗效,观察其对细胞免疫及炎症因子的影响,为临床治疗提供依据。方法:选取2014年1月到2016年2月我院收治的重症肺炎患者110例,将患者分为研究组和对照组,每组55例,对照组常规治疗,研究组加用血必净注射液治疗,比较两组临床疗效,比较治疗前后两组白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)、CD4+、CD8+以及自然杀伤细胞(NK)。结果:研究组总有
2、效率96.4%(53/55)显著高于对照组的83.6%(46/55)(P<0.05);治疗后两组IL-1、IL-6和TNF-a显著低于治疗前(P<0.05),且研究组显著低于对照组(P<0.05);治疗后两组CD4+、NK细胞显著升高,CD8+显著低于治疗前(P<0.05),研究组CD4+、NK显著高于对照组(P<0.05),CD8+显著低于对照组(P<0.05)。结论:血必净注射液治疗重症肺炎具有较好的临床疗效,能降低炎症反应,增强细胞免疫。【关键词】血必净;重症肺炎;免疫;炎症因子Effectitseffectoncellularimmunit
3、yandinflammatoryfactorsofXuebijingInjectiononpatientswithseverepneumoniaCHENShan(Respirology Department,Hainanagriculturalreclamationgeneralhospital,HainanHaikou570311)[Abstract]Objective:TostudytheclinicalcurativeeffectofXuebijingInjectiononpatientswithseverepneumonia,toobser
4、vetheeffectoncellularimmunityandinflammatoryfactors,toprovidebasisforclinicaltreatment.Methods:110casesofseverepneumoniainourhospitalfromJanuary2014toFebruary2016wereselected,thepatientsweredividedintothestudygroupandthecontrolgroup,55casesineachgroup,thecontrolgroupreceivedro
5、utinetreatment,thestudygroupplusXuebijinginjectiontreatment,theclinicaleffectoftwogroupswerecompared,interleukin1(IL-1)andinterleukin6(IL-6),tumornecrosisfactor-A(TNF-a),CD4+,CD8+andnaturalkiller(NK)cellsbeforeandaftertreatmentintwogroupswerecompared.Results:Thetotaleffectiver
6、ateofthestudygroupwas83.6%(53/55)wassignificantlyhigherthanthatof83.6%(46/55)inthecontrolgroup(P<0.05);aftertreatmentIL-1,IL-6andTNF-aoftwogroupsweresignificantlylowerthanthosebeforetreatment(P<0.05),andthestudygroupwassignificantlylowerthanthecontrolgroup(P<0.05);aftertreatme
7、ntCD4+andNKcellsoftwogroupsweresignificantlyincreased(P<0.05),CD8+wassignificantlylowerthanbeforetreatment(P<0.05),CD4+andNKinthestudygroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0.05),CD8+wassignificantlylowerthanthecontrolgroup(P<0.05).Conclusion:Xuebijinginjecti
8、oninthetreatmentofseverepneumoniahasgoodclinicalcurativeeffec