英文资料 Safety and efficacy of desmopressin for the treatment of nocturia in elderly patients: a cohort study
英文资料 Safety and efficacy of desmopressin for the treatment of nocturia in elderly patients: a cohort study
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1、Int Urol NephrolDOI 10.1007/s11255-014-0679-0UROLOGY - ORIGINAL PAPERSafety and efficacy of desmopressin for the treatment of nocturiain elderly patients: a cohort studyMiho Song • Bum Sik Hong • Ji-Youn Chun•Ji-Yeon Han • Myung-Soo ChooReceived: 14 November 2013 / Accep
2、ted: 19 February 2014Springer Science+Business Media Dordrecht 2014AbstractPurposeDesmopressin is used widely to treat nocturnalpolyuria (NP), but there is concern of hyponatremia espe-cially in elderly patients. This study aimed to evaluate thesafety and efficacy of long
3、-term desmopressin treatment inelderly patients with NP.MethodsPatients who were C65 years old with NP wereanalyzed. All patients were started on 0.1 mg desmopres-sin, and the dose was escalated to 0.2 mg depending onpatient symptoms. All patients were educated the mecha
4、-follow-up (p = 0.003). Hyponatremia incidence was4.4 %, and all patients recovered by stopping medication.Severe adverse events were not observed. The mean night-time frequency had decreased by 2.1, and the NUV haddecreased by 374.2 ± 261.3 mL at the last follow-up(p
5、 0.001).Conclusions Desmopressin at doses below 0.2 mg is safeand effective in elderly patients with NP if patients are wellinformed and are closely followed up.nism of desmopressin. The voiding diary and serumsodium levels were evaluated at baseline, 3–7 days afterstart
6、ing treatment and every 3–6 months. Safety wasKeywordsDesmopressin Nocturia Hyponatremiaevaluated by hyponatremia, hyponatremic symptoms andother adverse drug events. The mean changes in number ofnocturia and nocturnal urine volume (NUV) were evalu-ated for efficacy.Res
7、ultsA total of 68 patients were included. The meanage was 72.6 (66–85) years. The mean night-time fre-quency was 3.0 ± 1.8 day, and the mean serum sodiumlevel was 141.2 ± 2.1 mEq/L at baseline. The mean fol-low-up period was 27.9 months. The mean decrease inserum sodium
8、level was 1.3 ± 3.4 mEq/L at the lastMiho Song and Bum Sik Hong have contributed equally to this work.M