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1、10582J.Agric.FoodChem.2008,56,1058210593Absorption,UptakeandTissueAffinityofHigh-Molecular-WeightHyaluronanafterOralAdministrationinRatsandDogsLAJOSBALOGH,ANDRASPOLYAK,DOMOKOSMATHE,REKAKIRALY,JULIANATHUROCZY,MARIANTEREZ,GYOZOJANOKI,YAOTINGTING,§,
2、LUKER.BUC
3、CI,ANDALEXANDERG.SCHAUSS*DepartmentofAppliedRadioisotopes,NationalF.J.C.ResearchInstituteforRadiobiologyandRadiohygiene,FodorJo´zsefNationalCenterofHealth,Budapest,Hungary,FenChemBiotekLTD,Nanjing,China,SchiffNutritionGroup,SaltLakeCity,Utah,andLifeScienc
4、esDivision,AmericanInstituteforBiosocialandMedicalResearch,Inc.,Puyallup,Washington99mThepurposeofthisstudywastodeterminetheabsorption,distributionandexcretionoftechnetium-99m99m99mlabeled,high-molecular-weighthyaluronan((Tc-HA)andtechnetiumpertechnetate(
5、Tc-P)99maftersingledose,oraladministrationtoWistarratsandBeagledogs.ApilotstudyutilizedTc-HA99m99malone,andasecondconfirmatorystudycompareduptakeoflabeledTc-HAwithTc-P.Urinary99mandfecalexcretionafterTc-HAingestionbyratsshowed86.7-95.6%ofradioactivitywas99
6、mrecovered,almostallinfeces.AlltissuesexaminedshowedincorporationofradioactivityfromTc-99mHAstartingat15minandpersistingfor48h,inapatternsignificantlydifferentfromTc-P.Whole-bodyscintigraphsandclose-upsoftheventralchestregionshowednonalimentaryradioactivit
7、yfrom99mTc-HAconcentratedinjoints,vertebraeandsalivaryglandsfourhoursafteradministration.Autoradiographyofskin,boneandjointtissuepiecesafter24hshowedincorporationofradioactivity99m99m99mfromTc-HA,butnotfromTc-P.Conversely,absorption,distributionandexcreti
8、onofTc99mwascompletelydifferentfromTc-HA,showinganexpectedpatternofrapidabsorptionandexcretioninurine,withaccumulationinthyroidglands,stomach,kidneyandbladder.Thisreportpresentsthefirstevidenceforuptakeanddistributiontoconnectivetissuesoforallyadministered
9、,high-molecular-weightHA.99mKEYWORDS:Hyaluronan;oralabsorption;technetium;scintigraphy;dietarysupplements;jointtissuesINTRODUCTIONtheUnitedStatesaloneshowthatHAiswidelyconsumed,inadditiontoamountsnormallypresentinan
