雷诺昔酚对去势后大鼠骨密度、血生化指标的影响

《雷诺昔酚对去势后大鼠骨密度、血生化指标的影响》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、雷诺昔酚对去势后大鼠骨密度、血生化指标的影响【关键词】,卵巢切除术InfluenceofSERMraloxifeneonbonemineraldensityandbloodbiochemicalparametersinovariectomizedrats　　【Abstract】AIM:Tostudytheinfluenceofraloxifene(RAL),aselectiveestrogenreceptormodulator(SERM),onbonemineraldensity（BMD）lossincancell

2、atedboneandpactboneofovariectomizedrats.METHODS:TaleSDratsoperationgroup,ovariectomized（OVX）groupandtherapeutic（OVX+RAL）group.BilateralovariectomiesedinOVXgroupandOVX+RALgroup.ThelatteralfemoralsegmentandfemoralshafteasuredbydualenergyXrayabsorptiometry(DEXA).

3、L2vertebraeorphometricallyanalyzedandserumbiochemicalmarkerseasuredbeforeandafterdrugadministration.RESULTS:Serumtotalcalcium［（3.02±0.38）mmol/Lvs（2.24±0.30）mmol/L］andtotalalkalinephosphatase［（2.336±0.032）μkat/Lvs（1.832±0.028）μkat/L］significantlyincreasedinOVXg

4、roupparedgroup(P<0.01,P<0.05respectively).TheaboveparametersdecreasedinRALgroupparedizedgroup［（2.38±0.39）mmol/Lvs（3.02±0.38）mmol/L,（1.952±0.023）μkat/Lvs（2.336±0.032）μkat/L］(P<0.05).Sixteeny,BMDofL3L5vertebrae,proximalfemoralsegment［（0.181±0.021）g/cm2v

5、s（0.287±0.025）g/cm2］andfemoralshaft［（0.157±0.034）g/cm2vs（0.260±0.039）g/cm2］decreasedsignificantly(P<0.01)andthetrabecularbecamethinandirregularparedgroup.AftertreatmentofRAL,theaboveparametersrestored(P<0.05)butnottothelevelofshamgroup(P>0.05).CONCLUS

6、ION:Ovariectomyinducesasignificantdecreaseofcancellatedbonemassandpactbonemass.RALisaneffectivemedicinetoinhibitboneloss,increasetheBMDoflumbarspine,totalhipboneandtotalbodyanddecreasetheboneturnover.　　【Keyy；osteoporosis;selectiveestrogenreceptormodulator；ralo

7、xifene;metabolism;bonedensity　　【摘要】目的：研究选择性雌激素受体调节剂(SERM)雷诺昔酚（RAL）对去势后雌性大鼠血生化及骨密度(BMD)的影响.方法：将5mo龄未经产雌性二级SD大鼠24只，随机分为假手术(Sham)组、去势(OVX)组、去势＋RAL(OVX+RAL)组.OVX+RAL组大鼠术后7d开始给药.术后16组相比较，血钙（Ca2+）明显增高［（3.02±0.38）mmol/Lvs（2.24±0.30）mmol/L,P<0.01］，血碱性磷酸酶(ALP)升高［（2.

8、336±0.032）μkat/Lvs(1.832±0.028)μkat/L,P<0.05］，血磷(P)无明显差异.OVX+RAL治疗组与OVX组相比，血清Ca2＋，ALP均降低［（2.38±0.39）mmol/Lvs(3.02±0.38)mmol/L,(1.952±0.023)μkat/Lvs(2.336±0.032)μkat/L,P<0.05］