原发性高血压患者血清apelin与脂联素的相关性研究

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1、原发性高血压患者血清apelin与脂联素的相关性研究李庆辉1﹡杨天伦1谭碧峰2周环11.中南大学湘雅医院心内科,湖南长沙410008；2.怀化医学高等专科学校附属怀化市第三人民医院心内科,湖南怀化418000.）【摘要】目的观察原发性高血压(EH)患者和健康人血清apelin-13和脂联素(APN)水平及两者之间的相关性，探讨脂肪细胞因子apelin-13在EH中的作用及其相关影响因素。方法选取EH患者35例和健康人32例，用酶联免疫吸附法测定两组血清apelin-13和APN水平。结果①EH患者血清apelin-13和APN浓度显著低于健康对照组（17.61±6.52）pg/m

2、LVS（29.58±15.19）pg/mL；（197.55±54.48）µg/LVS（248.29±35.32）µg/L，均(P<0.01)；②经多元线性回归分析显示，EH患者血清apelin-13与收缩压呈显著负相关(r=－4.616，P<0.01），与APN呈正相关(r=2.480,P<0.05）。结论EH患者血清apelin-13水平降低，并与APN呈正相关，提示apelin-13可能通过影响APN水平而参与高血压的发生发展。关键词高血压病；apelin-13；脂联素CorrelationbetweenSerumApelin-13andAdiponectinlevelsin

3、PatientswithEssentialHypertension.LIQing-hui1YANGTian-lun1TANBi-feng2ZHOUHuan1(1DepartmentofCardiology,XiangyaHospitalofCentralSouthUniversity,Changshahunan410008，China2.DepartmentofCardiology,ThethirdPeople’sHospitalofHuaihuaCityAffiliatedtoHuaihuaMedicalCollege,Huaihuahunan418000,China.)【Ab

4、stract】ObjectiveToinvestigatetherelationshipbetweenserumapelinandadiponectinlevelsinpatientswithessentialhypertension.MethodsSerumapelinandadiponectinlevelsweredeterminedbyenzyme-linkedimmunosorbentassayin35patientswithessentialhypertensionand32healthycontrols.Results①Comparedwithcontrolgroup

5、,theserumconcentrationofapelin-13andadiponectinofpatientswithessentialhypertensionweregreatlylowered（17.61±6.52）pg/mLVS（29.58±15.19）pg/mL；（197.55±54.48）µg/LVS（248.29±35.32）µg/L，both(P<0.01).②Bytheanalysisofmultiplelinearregression,theresultshowsthattheserumconcentrationofapelin-13werenegative

6、lycorrelatedwiththesystolicbloodpressureofpatientswithessentialhypertension(r=－4.616，P<0.01），andserumapelin-13levelwere﹡李庆辉现工作于湖南农业大学医院心内科，通讯作者：杨天伦，E-mail:tianluny@163.compositivelycorrelatedwithadiponectin(r=2.480,P<0.05）.Conclusions.Serumapelin-13concentrationisdecreasedinthepatientswithess

7、entialhypertension,andpositivelycorrelateswithadiponectin.Apelin-13mightbeinvolvedinthepathogenesisbyinhibitingAPNsecretion.Keywords:essentialhypertension；apelin-13；adiponectin原发性高血压病(essentialhypertension，EH)是最常见的心血管疾病，其发病率在全球范围内呈逐年增加趋势，是严重威