资源描述：
《effects of heavy ion radiation.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Availableonlineatwww.sciencedirect.comAdvancesinSpaceResearch47(2011)37–48www.elsevier.com/locate/asrAmodeloftheeffectsofheavyionradiationonhumantissuea,b,⇑cdeArtemL.Ponomarev,AlameluSundaresan,MarceloE.Vazquez,PeterGuida,ebAngelaKim,FrancisA.CucinottaaUSRA,3
2、600SpaceCenterBlvd.,Houston,TX77058,USAb2101NASAParkway,HumanAdaptationandCountermeasuresDivision,MailCodeSK,NASAJohnsonSpaceCenter,Houston,TX77058,USAc3100CleburneSt.,DepartmentofBiology,TexasSouthernUniversity,Houston,TX77004,USAdNationalSpaceBiomedicalRes
3、earchInstitute,BaylorCollegeofMedicine,OneBaylorPlaza,Houston,TX77030-3498,USAeBrookhavenNationalLaboratory,Upton,NY11973,USAReceived8January2010;receivedinrevisedform9July2010;accepted9August2010AbstractInheavyionradiotherapyandspacetravelhumansareexposedto
4、energeticheavyions(C,Si,Feandothers).ThistypeofirradiationoftenproducesmoreseverebiologicaleffectsperunitdosethanmorecommonX-rays.AnewMonteCarlomodelgeneratesaphysicalspacewiththecomplexgeometryofhumantissueoracellculturebasedmodeloftissue,whichisaffectedbythe
5、passageofionizingradiation.Forirradiation,themodelreliesonaphysicalcodefortheiontrackstructure;fortissues,cellularmapsarederivedfromtwo-orthree-dimensionalconfocalmicroscopyimagesusingimagesegmentationalgorithm,whichdefinescellsaspixilatedvolumes.Themodelisus
6、edtostudytissue-specificstatisticsofdirectionhitsandtheremoteionactiononcells.Asanapplicationofthetechnique,weconsideredthespatialpatternofapoptoticcellsafterheavyionirradiation.Thepatternofapoptosisismodeledasastochasticpro-cess,whichisdefinedbytheactioncross
7、sectiontakenfromavailableexperimentaldata.Tocharacterizethedegreeofapoptosis,anautocorrelationfunctionthatdescribesthespatialcorrelationofapoptoticcellsisintroduced.Thevaluesoftheautocorrelationfunctiondemonstratetheeffectofthedirectionalityoftheradiationtrac
8、konthespatialarrangementsofinactivatedcellsintissue.Thiseffectisintrinsiconlytohighlinear-energy-transferradiation.Ó2010COSPAR.PublishedbyElsevierLtd.Allrightsreserved.Keywords:Heavyions;Tissueir
