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ID:33956014
大小:1.73 MB
页数:34页
时间:2019-03-02
《脑卒中患者血同型半胱氨酸与血脂各项指标检测结果评价及相关性研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、河北医科大学硕士学位论文脑卒中患者血同型半胱氨酸与血脂各项指标检测结果评价及相关性研究姓名:狄琢玉申请学位级别:硕士专业:神经病学指导教师:贺丹201203中文摘要脑卒中患者血同型半胱氨酸与血脂各项指标检测结果评价及相关性研究摘要目的:研究同型半胱氨酸(homocysteine,Hey)和血脂与脑卒中的关系,探讨Hey是否可以作为脑卒中的独立生化检测指标,研究Hey与脑卒中类型、病程、病灶大小和部位以及颈动脉斑块和狭窄的相关性,为临床早期诊断和治疗脑卒中提供新的实验依据。方法:1)选择98例脑卒中患者和96例正常的健康体检者为研究对象,检测Hcy和血脂水平,并进行对比分析;2)选择80例脑卒中
2、患者为研究对象,分别测定不同卒中类型、病程及病灶大小和部位的血清Hey水平,并进行对比分析;3)选择88例脑卒中患者和60例正常的健康体检者为研究对象,检测Hey,对Hey水平与颈动脉斑块和狭窄进行相关性分析。结果:1脑卒中患者组血清Hcy、甘油三酯(triglyceride,TG)、总胆固醇(totalcholesterol,TC)、低密度脂蛋白.胆固醇(10wdensitylipoprotein.cholesterol,LDL—C)明显高于对照组,且具有显著性差异(P3、erol,HDL--C)、LDL—C均无明显相关性(r值分别为0.08、O.05、0.06和0.03,P>O.05)。2脑卒中类型,病程及病灶大小和部位之间的血清Hey水平差异均无统计学意义(均P>O.05)。3脑血管病组的Hey水平和颈总动脉内膜.中层厚度均明显高于对照组,且两者之间均具有显著性差异(P4、ey水平基本没有影响。3高Hcy水平可能对颈动脉斑块和狭窄产生影响,导致脑卒中的发生和加重。4Hcy作为独立的缺血性脑血管疾病的致病因素,可在健康体检中作为重要的风险指标。关键词:同型半胱氨酸;血脂;脑卒中;相关性英文摘要Evaluationofpatientswithstrokeinbloodhomocysteineand—ipidindicatorsandrelatedstudieslipidindicatorsandrelatedstudiesABSTRACTObjective:Tostudytherelationshipbetweenhomocysteine(Hey),lipidsan5、dstroke,toexplorewhetherHcycallbeusedasasensitivebiochemicalmarkerofstroke,toinvestigatethecorrelationbetweenHcyandtype,duration,size,locationofthelesion,carotidarteryplaqueandstenosisofstroke,andtoprovidenewexperimentevidencefortheearlydiagnosisandtreatmentofstroke.Methods:1)Selectedthe98patientswi6、thstrokeand96normalhealthysubjects,detectedthelevelsofHcyandlipid,andcomparativelyanalyzedthechanges;2)Selected80patientswithstroke,measuredtheserumHcylevelindifferentstroketype,duration,lesionsizeandlocation,andcomparativeanalyzedsthechanges;3)Selectedthe88patientswithstrokeand60normalhealthysubjec7、ts,detectedofHcy,Hcylevelsandcarotidarteryforplaqueandstenosiswereanalyzed.Results:lTheserumHey,TGTCandLDL—Clevelofpatientswithstrokeweresignificantlyhigherthanthatofthehealthycontrolgroup,andhasasign
3、erol,HDL--C)、LDL—C均无明显相关性(r值分别为0.08、O.05、0.06和0.03,P>O.05)。2脑卒中类型,病程及病灶大小和部位之间的血清Hey水平差异均无统计学意义(均P>O.05)。3脑血管病组的Hey水平和颈总动脉内膜.中层厚度均明显高于对照组,且两者之间均具有显著性差异(P4、ey水平基本没有影响。3高Hcy水平可能对颈动脉斑块和狭窄产生影响,导致脑卒中的发生和加重。4Hcy作为独立的缺血性脑血管疾病的致病因素,可在健康体检中作为重要的风险指标。关键词:同型半胱氨酸;血脂;脑卒中;相关性英文摘要Evaluationofpatientswithstrokeinbloodhomocysteineand—ipidindicatorsandrelatedstudieslipidindicatorsandrelatedstudiesABSTRACTObjective:Tostudytherelationshipbetweenhomocysteine(Hey),lipidsan5、dstroke,toexplorewhetherHcycallbeusedasasensitivebiochemicalmarkerofstroke,toinvestigatethecorrelationbetweenHcyandtype,duration,size,locationofthelesion,carotidarteryplaqueandstenosisofstroke,andtoprovidenewexperimentevidencefortheearlydiagnosisandtreatmentofstroke.Methods:1)Selectedthe98patientswi6、thstrokeand96normalhealthysubjects,detectedthelevelsofHcyandlipid,andcomparativelyanalyzedthechanges;2)Selected80patientswithstroke,measuredtheserumHcylevelindifferentstroketype,duration,lesionsizeandlocation,andcomparativeanalyzedsthechanges;3)Selectedthe88patientswithstrokeand60normalhealthysubjec7、ts,detectedofHcy,Hcylevelsandcarotidarteryforplaqueandstenosiswereanalyzed.Results:lTheserumHey,TGTCandLDL—Clevelofpatientswithstrokeweresignificantlyhigherthanthatofthehealthycontrolgroup,andhasasign
4、ey水平基本没有影响。3高Hcy水平可能对颈动脉斑块和狭窄产生影响,导致脑卒中的发生和加重。4Hcy作为独立的缺血性脑血管疾病的致病因素,可在健康体检中作为重要的风险指标。关键词:同型半胱氨酸;血脂;脑卒中;相关性英文摘要Evaluationofpatientswithstrokeinbloodhomocysteineand—ipidindicatorsandrelatedstudieslipidindicatorsandrelatedstudiesABSTRACTObjective:Tostudytherelationshipbetweenhomocysteine(Hey),lipidsan
5、dstroke,toexplorewhetherHcycallbeusedasasensitivebiochemicalmarkerofstroke,toinvestigatethecorrelationbetweenHcyandtype,duration,size,locationofthelesion,carotidarteryplaqueandstenosisofstroke,andtoprovidenewexperimentevidencefortheearlydiagnosisandtreatmentofstroke.Methods:1)Selectedthe98patientswi
6、thstrokeand96normalhealthysubjects,detectedthelevelsofHcyandlipid,andcomparativelyanalyzedthechanges;2)Selected80patientswithstroke,measuredtheserumHcylevelindifferentstroketype,duration,lesionsizeandlocation,andcomparativeanalyzedsthechanges;3)Selectedthe88patientswithstrokeand60normalhealthysubjec
7、ts,detectedofHcy,Hcylevelsandcarotidarteryforplaqueandstenosiswereanalyzed.Results:lTheserumHey,TGTCandLDL—Clevelofpatientswithstrokeweresignificantlyhigherthanthatofthehealthycontrolgroup,andhasasign
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