脐血vcam-1、e-选择素水平与早产儿脑损伤关系的临床研究

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1、授予单位代码10089学号或申请号20123177HebeiMedicalUniversity硕士学位论文专业学位脐血VCAM-1�E-选择素水平与早产儿脑损伤关系的临床研究研究生：刘盡导师：江莲教授专业：儿科学二级学院：第四医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大

2、学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人己经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：4石、导师签章：>化年一？曰目录中文摘要·············································································

3、1英文摘要·············································································4英文缩写·············································································9研究论文脐血VCAM-1、E-选择素水平与早产儿脑损伤关系的临床研究前言··························································

4、···················11材料与方法····································································11结果·············································································15附图·············································································17附

5、表·············································································20讨论·············································································23结论·············································································28参考文献·············

6、··························································28综述VCAM-1、E-选择素在缺血性脑损伤中的作用·····················33致谢···················································································47个人简历····························································

7、·················48中文摘要脐血VCAM-1、E-选择素水平与早产儿脑损伤关系的临床研究摘要在存活早产儿当中比较常见的并发症为早产儿脑损伤(braininjuryinprematureinfants)，是致使新生儿发生死亡以及儿童神经系统伤残的关键因素之一。随着近些年来医学诊疗技术的突飞猛进，早产儿的的存活率得到显著增高，但仍有部分存活早产儿遗留下严重的神经系统后遗症，如认知、运动及社会适应等障碍。因此早产儿脑损伤的早期预防、早期诊断对于降低其发病几率以及减少其所引起的神经系统后遗症就显得尤为重

8、要。导致早产儿脑损伤发生的常见病因包括：围产期的缺氧缺血、感染和炎症反应等等。其中以围产期缺氧缺血最为显著。目前的诊断标准对于早产儿脑损伤主要是参考临床表现及头颅影像学检查（如通过经囟门彩超，颅脑CT，颅脑磁共振成像）。近些年来，随着对脑损伤发病机制研究的逐步展开，越来越多的人开始关注粘附分子在脑损伤中的水平变化及其发挥的作用。血管内皮细胞粘附分子-1（humanvasc