妊娠期肝内胆汁淤积症地塞米松治疗对胎儿垂体肾上腺功能影响的初步研究

《妊娠期肝内胆汁淤积症地塞米松治疗对胎儿垂体肾上腺功能影响的初步研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、第三军医大学硕士学位论文常用英文缩写一览表缩写英文名称中文名称ALPalkalinephosphatase碱性磷酸酶ALTalanineaminotransferase丙氨酸氨基转移酶ASTaspartateaminotransferase天冬氨酸氨基转移酶ACTHAdrenocorticotrophichormone垂体促肾上腺皮质激素DHEAdehydroepiadrosterone肾上腺脱氢表雄酮EE17--ethinylestradiol乙炔雌二醇GCglycocholicacid胆酸HEhematoxylin-eosinstaining苏木素-伊红染色ICPi

2、ntrahepaticcholestasisofpregnancy妊娠期肝内胆汁淤积症IHCImmunohistochemistry免疫组织化学IUGRintrauterinegrowthretardation胎儿宫内发育迟缓IODintegraopticaldensity积分光密度PBSphosphatebufferedsaline磷酸盐缓冲液PGpropyleneglycol丙二醇RIARadioimmunoassay放射免疫分析法TBAtotalbile总胆汁酸TBiLtotalbilirubin总胆红素RDSrespiratorydiseasesyndrome呼

3、吸窘迫综合征1第三军医大学硕士学位论文Studyoftheeffectsofdesamethasoneforintrahepaticcholestasisofpregnancyonfetalpituitary-adrenalfunctionsAbstractIntrahepaticcholestasisofpregnancy(ICP),aspecifichepaticdiseaseduringgestationalperiod,ismainlyencounteredinthemiddleorlatestageofpregnancy,presentingcharacter

4、isticssuchasskinitch,increaseinserumbileacid,mildtomoderateabnormalityofliverfunctions.ThedefinitecausesofICParenotwellknown.However,manypreviousepidemiologicalandexperimentalstudieshaveshownthatestrogenplaysanimportantroleinICP.Desamethasonecandecreasethesecretionofdehydroepiadrosterone

5、(DHEA)inthefetaladrenalgland,resultingindecreasedproductionofestrogenandattenuatedcholestasis,andcanalsopromotethematurationoffetallungs.Therefore,desamethasoneistheoptimalmedicineforthetreatmentofICP.Desamethasonecancausesideeffect.Animalandclinicalstudiesofglucocorticoid(GG)forthetreat

6、mentoflungmaturationoftheprematureinrecentyearsshowedthatrepeatedprenataladministrationofGGcouldleadtoharmfuleffectssuchasinhibitionoffetalgrowth,postponementofmyelinsheathformation,andneonatalsepticemia.Largertherapeuticdoseofdesamethasonewithlongertreatmentcourseisrequiredforthetreatme

7、ntofICPthanthatforthesimplepromotionoflungmaturationofthepremature.However,itisnotwellknownwhetherornotdesamethasoneforthetreatmentofICPhaseffectsandtowhatextentonthefetalpituitary-adrenalfunctions.Toexploretheeffectsofdesamethasoneonthefetalpituitary-adrenalfunctions,ICP