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1、Int.J.Cancer:120,2466–2473(2007)'2007Wiley-Liss,Inc.Aprospectivestudyofdietarycalcium,dairyproductsandprostatecancerrisk(Finland)PanagiotaN.Mitrou1*,DemetriusAlbanes1,StephanieJ.Weinstein1,PirjoPietinen2,PhilipR.Taylor1,21JarmoVirtamoandMichaelF.Leitz
2、mann1DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,NationalInstitutesofHealth,Rockville,USA2DepartmentofHealthPromotionandChronicDiseasePrevention,NationalPublicHealthInstitute,Helsinki,FinlandHighdietaryintakesofcalciumanddairyprodu
3、ctshavebeenaddressedinpreviousstudiesofcalcium/dairyandprostatecancer.hypothesizedtoenhanceprostatecancerrisk,butavailableprospec-TheATBCstudywasconductedinFinland,whichischaracter-tivedataregardingtheseassociationsareinconsistent.Weexaminedizedbyhigh
4、dairyproductconsumption17andthereforeprovidesdietaryintakesofcalciumanddairyproductsinrelationtoriskofanidealsettingforexaminingtheseassociations.prostatecancerintheAlpha-Tocopherol,Beta-Carotene(ATBC)CancerPreventionStudy,acohortof29,133malesmokersag
5、ed50–69yearsatstudyentry.Dietaryintakewasassessedatbaselineusingavalidated276-itemfoodusequestionnaire.Coxproportionalhaz-Materialandmethodsardsregressionwasusedtoadjustforknownorsuspectedriskfactorsforprostatecancer.During17yearsoffollow-up,weascerta
6、inedStudypopulation1,267incidentcasesofprostatecancer.Highversuslowintakeofdie-TheAlpha-Tocopherol,Beta-Carotene(ATBC)CancerPreven-tarycalciumwasassociatedwithamarkedincreaseinprostatecan-tionStudywasarandomized,doubleblind,placebocontrolled,2cerrisk.
7、Themultivariaterelativerisk(RR)ofprostatecancerforby2factorialdesign,primarypreventiontrialthattestedwhether2,000mg/daycomparedto<1,000mg/dayofcalciumintakewas1.63(95%confidenceinterval(CI),1.27–2.10;ptrend<0.0001).Totaldailysupplementationwithb-carot
8、ene(20mg)and/ora-tocoph-dairyintakewasalsopositivelyassociatedwithriskofprostatecan-erol(50mg)reducedtheincidenceoflungcancerinmalesmokerscer.ThemultivariateRRofprostatecancercomparingextremequin-recruitedfromsouthwesternFinlandbetween1985and1
