P1-修饰微乳液相色谱高通量测定药物亲脂性的分析

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1、广东药学院硕士研究生学位论文1.1仪器.................................................................................................................141.2药品与试剂.....................................................................................................142实验方法..................................................

2、..................................................................152.1溶液的配制.....................................................................................................152.2色谱条件.........................................................................................................152.3计算公式

3、.........................................................................................................162.4数据来源.........................................................................................................173结果与讨论.........................................................................

4、.......................................183.1SDS微乳体系的优化......................................................................................183.2P1修饰微乳液相色谱的建立.........................................................................223.3P1修饰微乳液相色谱模型对药物亲脂性的预测.........................................24

5、4小结............................................................................................................................32第三章优化P1修饰微乳液相色谱法和预测logBB......................................................341仪器与试药.....................................................................................

6、...........................341.1仪器.................................................................................................................341.2药品与试剂.....................................................................................................342实验方法...................................

7、.................................................................................352.1溶液的配制.....................................................................................................352.2色谱条