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1、NegishiCouplingTheNegishiCoupling,publishedin1977,wasthefirstreactionthatallowedthepreparationofunsymmetricalbiarylsingoodyields.Theversatilenickel-orpalladium-catalyzedcouplingoforganozinccompoundswithvarioushalides(aryl,vinyl,benzyl,orallyl)hasbroadscope,andisnotrestrictedtotheformationof
2、biaryls.MechanismoftheNegishiCouplingRecentLiteratureAnExtremelyActiveCatalystfortheNegishiCross-CouplingReactionJ.E.Milne,S.L.Buchwald,J.Am.Chem.Soc.,2004,126,13028-13032.One-PotNegishiCross-CouplingReactionsofInSituGeneratedZincReagentswithArylChlorides,Bromides,andTriflatesS.Sase,M.Jaric
3、,A.Metzger,V.Malakhov,P.Knochel,J.Org.Chem.,2008,73,7380-7382.EfficientNegishiCouplingReactionsofArylChloridesCatalyzedbyBinuclearandMononuclearNickel-N-HeterocyclicCarbeneComplexesZ.Xi,Y.Zhou,W.Chen,J.Org.Chem.,2008,73,8497-8501.TheFirstNegishiCross-CouplingReactionofTwoAlkylCentersUtilizi
4、ngaPd-N-HeterocyclicCarbene(NHC)CatalystN.Hadei,E.A.B.Kantchev,C.J.O'Brien,M.G.Organ,Org.Lett.,2005,7,3805-3807.NegishiCouplingofSecondaryAlkylzincHalideswithArylBromidesandChloridesC.Han,S.L.Buchwald,J.Am.Chem.Soc.,2009,131,7532-7533.EffectivePd-Nanoparticle(PdNP)-CatalyzedNegishiCouplingI
5、nvolvingAlkylzincReagentsatRoomTemperatureJ.Liu,Y.Deng,H.Wang,H.Zhang,G.Yu,B.Wu,H.Zhang,Q.Li,T.B.Marder,Z.Yang,A.Lei,Org.Lett.,2008,10,2661-2664.Nickel-CatalyzedAsymmetricNegishiCross-CouplingsofSecondaryAllylicChlorideswithAlkylzincsS.Son,G.C.Fu,J.Am.Chem.Soc.,2008,130,2756-2757.EfficientC
6、ross-CouplingofArylChlorideswithArylzincReagentsCatalyzedbyAmidoPincerComplexesofNickelL.Wang,Z.-X.Wang,Org.Lett.,2007,9,4335-4338.HighlyEfficient,GeneralProcedureforthePreparationofAlkylzincReagentsfromUnactivatedAlkylBromidesandChloridesS.Huo,Org.Lett.,2003,5,423-425.Zn-Mediated,Pd-Cataly
7、zedCross-CouplingsinWateratRoomTemperatureWithoutPriorFormationofOrganozincReagentsA.Krasovskiy,C.Duplais,B.H.Lipshutz,J.Am.Chem.Soc.,2009,131,15592-15593.Palladium-CatalyzedNegishiCross-CouplingReactionsofUnactivatedAlkylIodides,Bromides,Chlorides,andTo
