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1、316CurrentTopicsinMicrobiologyandImmunologyEditorsR.W.Compans,Atlanta/GeorgiaM.D.Cooper,Birmingham/AlabamaT.Honjo,Kyoto·H.Koprowski,Philadelphia/PennsylvaniaF.Melchers,Basel·M.B.A.Oldstone,LaJolla/CaliforniaS.Olsnes,Oslo·P.K.Vogt,LaJolla/CaliforniaPaulaM.P
2、itha(Ed.)Interferon:The50thAnniversaryWith35Figuresand8TablesPaulaM.PithaTheSidneyKimmelComprehensiveCancerCenterJohnsHopkinsSchoolofMedicine1650OrleansStreetBaltimore,MD21231USAe-mail:parowe@jhmi.eduCoverIllustration:ThepictureshowstheexpressionofKSHVenco
3、dedVIRF-3inBcells.LibraryofCongressCatalogNumber72-152360ISSN0070-217XISBN978-3-540-71328-9SpringerBerlinHeidelbergNewYorkThisworkissubjecttocopyright.Allrightsreserved,whetherthewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprin
4、ting,reuseofillustrations,recitation,broad-casting,reproductiononmicrofilmorinanyotherway,andstorageindatabanks.DuplicationofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLawofSeptember,9,1965,initscurrentversion,andperm
5、issionforusemustalwaysbeobtainedfromSpringer-Verlag.ViolationsareliableforprosecutionundertheGermanCopyrightLaw.SpringerisapartofSpringerScience+BusinessMediaspringeronline.com©Springer-VerlagBerlinHeidelberg2007Theuseofgeneraldescriptivenames,registeredna
6、mes,trademarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.Productliability:Thepublishercannotguaranteetheaccuracyofanyinformationabou
7、tdosageandapplicationcontainedinthisbook.Ineveryindividualcasetheusermustchecksuchinformationbyconsultingtherelevantliterature.Editor:SimonRallison,GuildfordDeskeditor:AnneClauss,HeidelbergCoverdesign:WMXDesign,HeidelbergTypesettingandProduction:SPi,IndiaP
8、rintedonacid-freepaperSPIN1188142127/3150/YL–543210PrefaceThismonographhasbeenwrittenagainstthebackgroundofthe50-yearanni-versaryofthediscoveryofinterferon(IFN),withtheaimofacknowledgingsomeoftheinitialworkas
