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1、analyzedthegenomeofthehumanA431wasalsodetected(Fig.2B,lane4).Weofteninvolvedinanonrandomrecipro-carcinomacellline,whichcontainsaconcludethatthehumanneugeneiscaltranslocationt(15;17)(q22:q21)inhighlyamplifiednumberofcopiesofthelocatedonq21ofchromosome17,inacutepromyelocyticleukemia(15).
2、ThegeneencodingtheEGF-r(4,10,11).TocontrasttothegeneencodingtheEGF-r,relationshipbetweenneuandhumanma-determinewhethertheneugenewaswhichisfoundonchromosome7.lignancyisunderinvestigation.coamplifiedinthiscellline,asetofThelocalizationofneucoincideswithnitrocellulosefilterswaspreparedcon
3、-themappositionofthehumanc-erbAlReferencesandNotestainingEcoRI-digestedDNAisolatedlocusat17pl1-q21(13).Thecellular1.C.Shih,L.Padhy,M.Murray,R.A.Weinberg,fromA431cellsandfromHeLacells;theerbAanderbBgenesofchickenhave2.NatureA.L.Schechter(London)et290,al.,261ibid.(1981).312,513(1984).DNA
4、fromHeLacells,anotherhumanbothbeenincorporatedintothegenome3.J.Downwardetal.,ibid.307,521(1984).4.A.Ullrichetal.,ibid.309,418(1984).tumorline,wasusedasacontrol.Whenofavianerythroblastosisvirus(14).The5.B.Vennstrom,L.Fanshier,C.Moscovici,J.M.thisfilterwashybridizedwiththeEGF-rsignifican
5、ceofthecoincidentalmappingBishop,J.Virol.36,575(1980).6.T.Hunter,Nature(London)311,414(1984).cDNAsubclone64-1,theA431celllineoftheerb-relatedneuandc-erbAlgenes7.M.Basuetal.,ibid.,p.477.wasobservedtocontainamplifiedDNAisobscureatpresent.9.8.J.Y.-H.Downward,Xuetal.,P.ibid.Parker,309,M.80
6、6D.(1984).Waterfield,ibid.segmentshomologoustotheprobe(Fig.WhiletheneuandEGF-rgenesare310,483(1984).2A).We,andotherinvestigators(4,10),distinctandunlinked,theyareclosely10.C.R.Linetal.,Science224,843(1984).11.G.T.Merlinoetal.,ibid.,p.417.havefoundthatsegmentshomologoustorelatedinatleas
7、toneregion,thatwhich12.P.MeerakkhanandM.Smith,Cytogenet.CellGenet.37,71(1984).otherdomainsofc-erbBarealsoampli-encodesthetyrosinekinasedomain.13.N.Spurretal.,EMBOJ.3,159(1984).fied.Ininitialstudies,wehybridizedaThus,theneugene,likeerbB,isamem-14.B.VennstromandJ.M.Bishop,Cell28,135(19
