冠状病毒Coronavirusl论文-1985 Studies on the relationship between coronaviruses from the intestinal and respiratory tracts of calves.pdf

冠状病毒Coronavirusl论文-1985 Studies on the relationship between coronaviruses from the intestinal and respiratory tracts of calves.pdf

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时间:2020-03-16

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1、ArchivesofVirologyArchivesofVirology85,71--83(1985)©bySpringer-Verlag1985StudiesontheRelationshipBetweenCoronavirusesfromtheIntestinalandRespiratoryTractsoiCalvesByD.J.REYNOLDS,T.G.DEBNEY,G.A.HALL,L.H.THO~AS,andK.t~.PAnso~sA.F.1%.C.Iastitutefor1%esear

2、chonAnimalDiseases,Compton,Newbury,Berkshire,UnitedKingdomWith3FiguresAcceptedNovember1,1984SummaryAnimmunofluorescencetestonsmearsofnasalepithelialcellswasusedtodetectcoronavirusinfectionintherespiratorytractofcalves.Thirteengnotobioticcalveswereinfe

3、ctedwithcoronavirusisolatesderivedfromfaecesorrespiratorymaterial:viruswasdetectedinfaecesandnasalswabsfromallanimals.In115calvesfromafieldsurvey,therewasasignificantassociationbetweencoronavirusexcretionfrombothrespiratoryandentericroutesincalveswith

4、diarrhoea.Inafurther12calves,atnecropsy,thepredilectionsitesforcoronavirusgrowthwerethedistalsmallintestine,largeintestineandtheepitheliaofthenasalcavityandtrachea.Antigenwasnotfoundinlungtissuebyimmunofluorescenceorimmunoperoxidasestaining.Infectionw

5、ithentericcoronavirusinducedimmunitytoreinfectionandtoheterologouschallengewithtwocoronavirusisolatesderivedfromtherespiratorytract.Ninecoronaviruseswerecultivated,clonedandantiseratothreewerepreparedinpigs.Therewascompletevirusneutralisationintestswi

6、thhomologousseraandsignificantcrossreactionswiththeeightotherisolateswhichwereofintestinalandrespiratoryorigin.Thus,thesebovinecoronavirusisolatesbelongedtothesameserotypedespitethesourceofvirus.Introdueti.nCoronavirusareimportantcausesofupperrespirat

7、orytractillness,encephalitis,hepatitisandentericdiseaseinhumansoranimals(27).The72D.J.REY~'OLDSetal.:intestineistheprimarysiteforreplicationoftransmissiblegastroeuteritisvirus(TGEV)ofpigs,canineandbovinecoronavirus(BCV).Virusreplicationcausespathologi

8、calchangesintheintestinalvillianddiarrhoeacanresult(10).Threecoronavirusesareconsideredtoberespiratorypathogens(14,21);theyareavianinfectiousbronchitisvirus(AIBV),ratcoronavirus(RCV)andhumancoronavirus(HCV).Cultureadapted(20)andfieldstrains(1)

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