绿色化学课件Ch6.ppt

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1、Chapter6:ProspectsandChallengesinGreenChemistry0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.Weng0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.WengOutline6.1KeyGreenChemistryResearchAreas6.2AmideFormation:avoidingpoorat

2、omeconomyreagents6.3AlcoholActivationforNucleophilicSubstitution6.4Reductionofamideswithouthydridereagents6.5Oxidation/EpoxidationMethods6.6C–HActivation6.7AsymmetricSynthesisofAminesfromProchiralKetones6.8Asymmetrichydrogenationofunfunctionalisedolefins/enamines/imi

3、nes6.9NewGreenerFluorinationMethods0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.Weng6.1KeyGreenChemistryResearchAreas-APerspectivefromPharmaceuticalManufacturersConstable,D.J.C.etal.GreenChem.2007,9,411.BrainstormIdeasReactionsweusenowbutwoul

4、dpreferbetterreagentsFrequencyofuseWasteassessmentProcesshazardassessmentAspirationalReactionlistKeyChallengesinPharmaManufacturingPrioritisebycompanyvoteGSKMerckPfizerLillySchering-PloughAZ0403809GreenChemistryChapter6:ProspectsandChallengesinGreenChemistryZ.WengGr

5、eenMitsunobuReactionsReductionofamidesavoidingLAHandDiboraneBrominationReactionsSulfonationreactionsAmideFormationavoidingpooratomeconomyreagentsNitrationreactionsF/CReactionsonunactivatedsubstratesDemethylationReactionsEsterHydrolysisOHactivationfornucleophillicsubs

6、titutionEpoxidationOxidationWittigChemistrywithout(Ph3PO)RadicalChemistrywithoutBu3SnHSolventlessReactorCleaningPolarAproticreplacementsforNMP,DMSO,DMAc,DMFetcAsymmetricHydrocyanationAldehydeorKetone+NH3+“X”togiveachiralamineN-Centredchemistryavoidingazideshydrazines

7、etcAsymmetricHydrolysisofnitrilesAsymmetricHydrogenationofunfunctionalisedolefins/enamines/iminesAsymmetricHydroformylationC-HactivationofaromaticsC-HactivationofalkylgroupsNewGreenFluorinationMethodsOxygenNucleophileswithhighreactivityGreensourcesofelectrophilicNitr

8、ogenAsymmetricHydroaminationofolefinsAsymmetricHydrationofolefinsOrganocatalysisROH+ArCltogiveROAr0403809GreenChemistryChapter6:Pro