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1、有机氯杀虫剂药理学organochlorineinsecticidesTheuseofDDTisstillacontroversialtopicandsometimes,politicalcorrectnessmayhavecontributedtolackofmalarialcontrolduetorestrictionofitsuse.2organochlorineinsecticidesIn2001theUnitedNationsDevelopmentProgrammeagreedthatDDTcouldbeusedincertaincircumstanc
2、estoprotectagainstmalariawhereresistancetoothervectorcontrolshaddevelopedespeciallyinthelightofitscontinuedeffectiveness.3organochlorineinsecticidesSymptomsIngeneral,thesignsofpoisoningproducedbydifferentorganochlorineinsecticidesaresimilar,thatisexpressionsofneuronalhyperactivity.4o
3、rganochlorineinsecticidesRoutesofabsorptionAllorganochlorineinsecticidescanbeabsorbedthroughtheskinaswellasbyrespiratoryandoralroutes,buttheimportanceofdermalabsorptionvariesgreatlyforthedifferentcompounds.5organochlorineinsecticidesDistribution,metabolismandexcretionOrganochlorinein
4、secticideshavebecomeinfamousbecauseoftheirtendencytoaccumulateinhumans,animals,birds,andthegeneralenvironment.6organochlorineinsecticidesAftersingleorrepeateddoses,mostofthesechemicalseventuallyreachtheirhighestconcentrationsinadiposetissue.Chlorinatedhydrocarboninsecticidescanbemeta
5、bolizedbymicrosomalP-450systemtohydroxylderivatives.7organochlorineinsecticidesParentinsecticidesusuallyareexcretedeitherinthebile,orpossiblythroughtheintestinalwall,forfaecalexcretion.Metabolitesareexcretedintheurineiftheyareofrelativelyhighpolaritysuchasglucuronides(葡(萄)糖苷酸).8organ
6、ochlorineinsecticidesEffectsontheliverDDTandotherorganochlorineinsecticidescausemarkedchangesintheliversofvariousrodents,andinsomespecies,especiallythemouse,thesechangesprogresstotumours.9organochlorineinsecticidesReproductiveinfluenceManyofthechlorinatedinsecticideshaveendocrinedisr
7、uptingproperties,perhapsbyactingasweakoestrogens.Somestudieshaveimplicatedachronicoxidativestressinmechanismsofteratologicalactionoforganochlorinepesticides.10Lindane1,2,3,4,5,6-Hexachlorocyclohexane(HCH)haseightseparablestericisomers.Lindane:GammaHCHγ-isomer,lindane:accountedforthei
8、nsecticidalp
