欢迎来到天天文库
浏览记录
ID:39751845
大小:4.14 MB
页数:34页
时间:2019-07-10
《植物皮肤脱色剂的研究进展1》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、植物皮肤脱色剂的研究进展ResearchAndDevelopmentOnPhyto-activesForSkinDepigmentation美与白Beautyandwhitening肤色决定因素皮肤内色素Pigmentsinskin黑素Melanin类胡萝卜素Carotenoid血红蛋白比例Ratioofhemoglobin皮肤厚薄Thicknessofskin表皮Epidermis真皮DermisCriticalfactorsforskincolor表皮黑素细胞的原子力显微镜观察Observationofepidermalmelanocytesunderatomforcemicrosco
2、pe(AFM)矛盾Conflicts化学剂-----天然植物Chemicalreagentsnaturalplants汞剂Mercurials氢醌Hydroquinone糖皮质激素Glucocorticoids效果好,安全性差Goodinefficacy,butbadinsafety研究流程1.植物筛选Plantscreening酪氨酸活性测定-蘑菇酪氨酸酶、人酪氨酸酶多巴色素自动氧化生成黑素测定Tyrosinaseactivitymeasurement-mushroomtyrosinaseandhumantyrosinaseDopamelaninautooxidationandmelan
3、informationmeasurement2.有效性安全性验证Efficacyandsafetytests黑素瘤细胞培养Melanomacellculture人表皮黑素细胞培养Humanmelanocytesculture豚鼠皮肤试验Guineapigskintest人临床效果观察Humanclinicalstudyandobservation3.活性基团,开发新药ActivegroupsandnewdrugdevelopmentStudyscheme酪氨酸多巴酪氨酸酶多巴醌谷胱甘肽or半胱氨酸多巴色素半胱氨酰多巴TRP-25,6-二羟吲哚5,6-二羟吲哚-2-羧酸(DHI)(DHICA
4、)TRP-1DHI多聚体DHICA多聚体优黑素褐黑素TRP-1(多巴色素互变异构酶)TRP-2(5,6-二羟吲哚-2-羟酸聚合酶)主要机制Primarymechanisms直接或间接抑制酪氨酸酶Directorindirectinhibitioneffectontyrosinase还原剂和活性氧族Reducingreagentandreactiveoxygenspecies降解酪氨酸酶Tyrosinasedegradation抑制黑素体转运Inhibitionofmelanosometransportation抑制炎症引起的合成黑素反应Inhibitionofinflammationind
5、ucedmelaninsynthesis加速表皮更新Accelerateturnoverrateofepidermis直接或间接抑制酪氨酸酶Directorindirectinhibitioneffectontyrosinase熊果苷Arbutin(熊果、沙梨树叶)(Arctostaphylosuva-ursiL.Spreng;P.pyrifolia(Burm.)Nakaitreeleaves)芦荟苦素Aloesin(芦荟,Aloe)甲酯龙胆酸2,5-Methylhydroxybenzoicacid(Gentisicmethyl)(龙胆)(GentianascabraBge)生物类黄酮Bi
6、oflavonoid山奈酚(银杏)Kaempferol(Gingko)芹菜素(芹菜)OleanolicAcid/Apigenin(Celery)柚皮素(柚)Naringenin(CitrusgrandisL.Osbeck)熊果苷(arbutin)抑制酪氨酸酶活性Inhibitionoftyrosinaseactivity抑制TRP-2活性InhibitiononTRP-2activity有效性Efficacy:黑素瘤细胞Melanoma人黑素细胞Humanmelanocytes动物模型Animalmodels人体临床试验Humanclinicalstudy熊果Arctostaphylosu
7、va-ursiL.Spreng熊果苷Arbutin熊果苷---------(Arbutin)Alpha-熊果苷--------(Alpha-arbutin)脱氧熊果苷-----------(Deoxyarbutin)芦荟苦素(aloesin)竞争性抑制多巴氧化Competetivelyinhibitondopaoxidation非竞争性抑制酪氨酸酶羟化Non-competetivelyinhibittyrosinaseh
此文档下载收益归作者所有