植物皮肤脱色剂的研究进展1

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1、植物皮肤脱色剂的研究进展ResearchAndDevelopmentOnPhyto-activesForSkinDepigmentation美与白Beautyandwhitening肤色决定因素皮肤内色素Pigmentsinskin黑素Melanin类胡萝卜素Carotenoid血红蛋白比例Ratioofhemoglobin皮肤厚薄Thicknessofskin表皮Epidermis真皮DermisCriticalfactorsforskincolor表皮黑素细胞的原子力显微镜观察Observationofepidermalmelanocytesunderatomforcemicrosco

2、pe(AFM)矛盾Conflicts化学剂-----天然植物Chemicalreagentsnaturalplants汞剂Mercurials氢醌Hydroquinone糖皮质激素Glucocorticoids效果好，安全性差Goodinefficacy，butbadinsafety研究流程1.植物筛选Plantscreening酪氨酸活性测定-蘑菇酪氨酸酶、人酪氨酸酶多巴色素自动氧化生成黑素测定Tyrosinaseactivitymeasurement-mushroomtyrosinaseandhumantyrosinaseDopamelaninautooxidationandmelan

3、informationmeasurement2.有效性安全性验证Efficacyandsafetytests黑素瘤细胞培养Melanomacellculture人表皮黑素细胞培养Humanmelanocytesculture豚鼠皮肤试验Guineapigskintest人临床效果观察Humanclinicalstudyandobservation3.活性基团,开发新药ActivegroupsandnewdrugdevelopmentStudyscheme酪氨酸多巴酪氨酸酶多巴醌谷胱甘肽or半胱氨酸多巴色素半胱氨酰多巴TRP-25，6-二羟吲哚5，6-二羟吲哚-2-羧酸(DHI)(DHICA

4、)TRP-1DHI多聚体DHICA多聚体优黑素褐黑素TRP-1（多巴色素互变异构酶）TRP-2（5，6-二羟吲哚-2-羟酸聚合酶）主要机制Primarymechanisms直接或间接抑制酪氨酸酶Directorindirectinhibitioneffectontyrosinase还原剂和活性氧族Reducingreagentandreactiveoxygenspecies降解酪氨酸酶Tyrosinasedegradation抑制黑素体转运Inhibitionofmelanosometransportation抑制炎症引起的合成黑素反应Inhibitionofinflammationind

5、ucedmelaninsynthesis加速表皮更新Accelerateturnoverrateofepidermis直接或间接抑制酪氨酸酶Directorindirectinhibitioneffectontyrosinase熊果苷Arbutin(熊果、沙梨树叶)(Arctostaphylosuva-ursiL.Spreng;P.pyrifolia(Burm.)Nakaitreeleaves)芦荟苦素Aloesin(芦荟,Aloe)甲酯龙胆酸2,5-Methylhydroxybenzoicacid(Gentisicmethyl)(龙胆)(GentianascabraBge)生物类黄酮Bi

6、oflavonoid山奈酚（银杏）Kaempferol(Gingko)芹菜素（芹菜）OleanolicAcid/Apigenin(Celery)柚皮素（柚）Naringenin(CitrusgrandisL.Osbeck)熊果苷(arbutin)抑制酪氨酸酶活性Inhibitionoftyrosinaseactivity抑制TRP-2活性InhibitiononTRP-2activity有效性Efficacy:黑素瘤细胞Melanoma人黑素细胞Humanmelanocytes动物模型Animalmodels人体临床试验Humanclinicalstudy熊果Arctostaphylosu

7、va-ursiL.Spreng熊果苷Arbutin熊果苷---------(Arbutin)Alpha-熊果苷--------(Alpha-arbutin)脱氧熊果苷-----------(Deoxyarbutin)芦荟苦素(aloesin)竞争性抑制多巴氧化Competetivelyinhibitondopaoxidation非竞争性抑制酪氨酸酶羟化Non-competetivelyinhibittyrosinaseh