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1、雌、孕激素受体在子宫肌瘤、子宫腺肌病中表达及其意义[摘要]目的探讨雌激素受体(ER)和孕激素受体(PR)在子宫肌瘤、子宫腺肌病病灶及其在位内膜组织中的表达情况。方法采用免疫组织化学染色法(Evision二步法)分别检测38例子宫肌瘤(肌瘤组)的肌瘤病灶和在位内膜及30例子宫腺肌病(腺肌病组)的腺肌病病灶和在位内膜中ER、PR的表达水平。结果肌瘤组和腺肌病组病灶的ER、PR表达水平明显低于在位内膜组织;肌瘤组中ER、PR表达均符合增生期高于分泌期的变化规律,腺肌病组ER、PR除在位内膜PR外均丧失周期性变化规律。结论子宫肌瘤的发生与雌、孕激素水
2、平及其受体含量的周期性变化有关,腺肌病病灶ER、PR的低表达和缺乏周期性变化及相应在位内膜ER也丧失周期性变化的特点可能与子宫内膜异位症的发生、发展有关。�[关键词]雌激素受体;孕激素受体;子宫肌瘤;子宫腺肌病�[中图分类号]R737.3;Q786[文献标识码]A[文章编号]1671-7562(2009)04-0268-03Significanceofdifferentexpressionsofestrogenreceptorand�progesteronereceptorin6hysteromyomaandadenomyosisWANGJi
3、n-wei�1,JIANGShu-juan�2,ZhangYu�1(1.DepartmentofObstetricsandGynecology,2.DepartmentofPathology,ShanghaiHuangpu�CentralHospital,Shanghai200002,China)�Abstract:ObjectiveToexplorethecharacteristicofdifferentexpressionsofestrogenreceptor(ER)andprogesteronereceptor(PR)inhystero
4、myoma,adenomyosisandendometriumtissues.MethodBytakingimmunohistochemicalstainingmethod(Evisionmethod),wecompared38hysteromyomacaseswith30adenomyosiscases,throughwhichwecangettherelevantconsistenciesofERandPRbytestingtherespectivedensitiesoftheminmyomatissuesandendometriumti
5、ssuesofhysteronyomaandadenomyomatissuesandendometriumtissuesofadenomyosis.ResultsInhysteromyomacases,theexpressionsofERandPRinmyomatissuesaresignificantlylowerthanthoseinendometriumtissues;whileinadenomyosiscases,theexpressionsofERandPRinadenomyomatissuesare6significantlylo
6、werthanthoseinendometriumtissues.Inhysteromyomacases,theexpressionsofERandPRarejustmatchingthechangerules,whicharestrongerinproliferativethanthatinsecretoryphase.Butinadenomyosiscases,excepttheexpressionofPRinendometriumtissues,theexpressionsofbothERandPRlosetheirperiodical
7、cycle.ConclusionsTheoccurrenceofhysteromyomaisrelatedtothelevelsofestrogenandprogesteroneandtheperiodicalcycleofexpressionsoftheirreceptors.Thelowexpressionsandnon-periodicalconsistencieschangepatternsofERandPRinadenomyomatissues,andthenon-periodicalconsistencychangepattern
8、sofERinendometriumtissuesmayassociatewiththeoccurrenceanddevelopmentofendometriosi
