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1、奥曲肽对胃癌术后血中VEGF及肠功能影响【摘要】目的探讨奥曲肽对胃癌术后VEGF及肠功能的影响。方法选择我院胃癌术后患者86例，将上述患者随机分为观察组和对照组各43例，正常健康对照组为正常体检者18例。两组患者均给予常规治疗。对照组患者患者术后不给任何刺激肠蠕动的药物；观察组患者给予奥曲肽，初次剂量为0.1mg，静脉注射，而后0.2~0.4mg加入250mL生理盐水中静脉24h持续滴注，3次/d，连续应用3~6d。正常健康对照组体检时、两组患者均于术后第二天及术后第7天空腹抽血5ml,采用ELISA法定量检测VEGF。结果胃肠功能恢复情况
2、，观察组优于对照组（P＞0.01）；术后2天、7天VEGF水平两组均高于正常对照组（P＞0.01）；术后7天VEGF水平均下降，观察组下降明显与对照组（P＞0.01）。结论奥曲肽能够显著提高胃癌术后患者VEGF，能够显著改善胃癌术后的胃肠动力，临床效果显著。【关键词】胃癌；血管内皮生长因子；奥曲肽；胃肠动力OctreotideongastriccancerafterbloodandintestinalfunctionofVEGFShunan,Ousanji,PenxiaohuiShiNanOuShanjiPenXiaohiu5【Abstra
3、ct】ObjectiveToinvestigatetheeffectsofoctreotideongastriccancerandintestinalfunctionofVEGF.Methodshospitalpatientswithgastriccancer,86casesoftheabovewererandomlydividedintotwogroupsandthecontrolgroup,43casesofnormalhealthycontrolgroupofnormalphysicalexaminationin18cases.All
4、patientsreceivedconventionaltherapy.Controlgrouppatientswerenotgivenanydrugstostimulatebowelmovements;observationgroupweretreatedwithoctreotide,theinitialdoseof0.1mg,intravenousinjection,then0.2~0.4mgadding250mL24hcontinuousinfusionofintravenousnormalsaline,3times/dcontinu
5、ousapplicationof3~6d.Normalhealthycontrolgroup,physicalexamination,patientsinbothgroupsatpostoperativedayand7daysafterthefastingblood5ml,usingELISAforquantificationofVEGF.Resultsoftherecoveryofgastrointestinalfunction,theobservationgroupthanthecontrolgroup（P＞0.01）;after2da
6、ys,7daysinbothgroupsVEGFlevelshigherthanthenormalcontrolgroup（P＞0.01）;7daysafterVEGFlevelswere5decreasedtheobservationgroupdecreasedsignificantlycomparedwiththecontrolgroup（P＞0.01）.ConclusionOctreotidesignificantlyincreasedgastriccancerpatientsVEGF,cansignificantlyimproveg
7、astriccancerofgastrointestinalmotility,asignificantclinicaleffect.【Keywords】Gastriccancer;vascularendothelialgrowthfactor;octreotide;gastrointestinalmotility【中图分类号】R362【文献标识码】B【文章编号】1005-0515(2011)07-0274-02胃癌是我国常见的恶性肿瘤，其手术时机基本已到晚期，手术损伤较大，术后肠功能恢复较差。血管内皮生长因子[1](vascularendo
8、thelialgrowthfactor，VEGF))在胃癌组织中高表达，对胃癌新生血管形成及肿瘤生长和转移起重要作用，已得到证实。其术后在肠功能恢复过程是否有变化如何，则鲜有报道
