Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion.[2017][Oncotarget][10.18632oncotarget.18322]

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1、www.impactjournals.com/oncotarget/Oncotarget,AdvancePublications2017Dragreducingpolymersdecreasehepaticinjuryandmetastasesafterliverischemia-reperfusionSamerTohme1,*,MarinaV.Kameneva1,2,3,*,HamzaO.Yazdani1,VikasSud1,JulieGoswami1,PatriciaLoughran1,4,HaiHuang1,RichardL.Simmons1andAllanTsun

2、g11DepartmentofSurgery,UniversityofPittsburghMedicalCenter,Pittsburgh,PA,USA2McGowanInstituteforRegenerativeMedicine,UniversityofPittsburgh,Pittsburgh,PA,USA3DepartmentofBioengineering,UniversityofPittsburgh,Pittsburgh,PA,USA4CenterforBiologicImaging,DepartmentofCellBiology,UniversityofPi

3、ttsburgh,PA,USA*TheseauthorshavecontributedequallytothisworkCorrespondenceto:SamerTohme,email:tohmest@upmc.eduKeywords:liver,Ischemiareperfusioninjury,dragreducingpolymers,livermetastasis,metastaticcolorectalcancerReceived:January09,2017Accepted:March10,2017Published:May31,2017Copyright:T

4、ohmeetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(CC-BY),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.ABSTRACTIntroduction:Surgery,acrucialtherapeuticmodalityinthetreatment

5、ofsolidtumors,caninducesterileinflammatoryprocesseswhichcanresultinmetastaticprogression.Liverischemiaandreperfusion(I/R)injury,aninevitableconsequenceofhepaticresectionofmetastases,hasbeenshowntofosterhepaticcaptureofcirculatingcancercellsandacceleratemetastaticgrowth.Effortstoreducethes

6、enegativeconsequenceshavenotbeenthoroughlyinvestigated.Dragreducingpolymers(DRPs)areblood-solublemacromoleculesthatcan,innanomolarconcentrations,increasetissueperfusion,decreasevascularresistanceanddecreasenear-wallmicrovascularconcentrationofneutrophilsandplateletstherebypossiblyreducing

7、theinflammatorymicroenvironment.WehypothesizethatDRPcanpotentiallybeusedtoamelioratemetastaticcaptureoftumorcellsandtumorgrowthwithintheI/Rliver.Methods:Experimentswereperformedutilizingasegmentalischemiamodelofmicelivers.Fivedayspriororimmediatelypriortoischemia,mu