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1、奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验中国骨伤2009年12月第22卷第12期ChinaJOnhop&Trauma,Dec.2009,Vo1.22.No.12?917?临床研究?奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验周彩云,潘峥,马芳,唐今杨(中国中医科学院西苑医院风湿免疫科,北京100091)【摘要】目的:评价奇正青鹏膏剂外用对类风湿关节炎关节疼痛肿胀的临床疗效.方法:自2004年12月至2006年5月采用随机,平行对照临床研究方案,运用区组随机化方法,利用SAS软件的PROCPLAN语句,将78例患者随机分为治疗
2、组和对照组.治疗组40例,男30例,女10例,平均年龄(48.2±9.7)岁,用奇正青鹏膏剂外用治疗;对照组38例,男30例,女8例,平均年龄(47.7±l3.7)岁,用双氯芬酸二乙胺乳胶剂外用.以掌指关节中肿痛最重的一个关节作为观察关节,观察关节疼痛,关节压痛,关节肿胀,关节屈伸不利,晨僵等情况,根据尼莫地平法计算症状积分指数WAS记分),进行疗效判定.结果:共有68例完成试验,治疗组35例,对照组33例.治疗2周末治疗组显效1例,有效27例,无效7例;对照组显效2例,有效20例,无效11例,两组疗效差异无统计学意义.但治疗1周末治疗组关节肿胀的评分为(4.0±
3、1.4)分,低于对照组的(5.5±1.9)分.结论:奇正青鹏膏荆治疗类风湿性关节炎与双氯芬酸二乙胺乳胶剂缓解关节疼痛疗效相当,奇正青鹏膏剂消肿作用更强.【关键词】关节炎,类风湿;外治法;中药疗法;临床对照试验ControlledclinicaltrialsofexternalusingofCheezhengQingpengointment(奇正青鹏膏)onrelivinganalgesiaandswellingforthetreatmentofrheumatoidarthritisZHOUCai—yun,PANZheng,MAFang,TANGn—yang.The
4、XiyuanHospitalofChinaAcademyofChineseMedicalSciences,Beijing100091,ChinaABSTRACTObjective:ToobservetheclinicalefficacyonanalgesiaanddetumescenceofCheezhengQingpengointment(奇正青鹏膏)inthetreatmentofrheumatoidarthritis.Methods:FromDecember2004toMay2006,78patientsweredividedintothetreatment
5、groupandthecontrolgrouprandomlyusingPROCPLANfromSASsoftware.Therewere40patientsinthetreatmentgroup.30patientsweremaleand10patientswerefemale,withanaverageageof(48.2-+9.7)years,whoweretreatedwithCheezhengQingpengointment(奇正青鹏膏)externaltreatment.Thirty—eightpatientswereinthecontrolgroup
6、,30pa—tientsweremaleand8patientswerefemale,withanaverageageof(47.7-+13.7)years,andweretreatedwithDiclofenacdi—ethylamineemuge1.Al1thepatientsweretreatedfor2weeks.Themetacarpophalangealjointwithmostseverepainandswellingwasobserved.Theindexesincludingjointpain,tenderness,swelling,jointm
7、otionandmorningstiffnessweredetectedandtheVASscoreswerecomparedbetweenthetwogroups.Results:Allthepatientscompletedthetrial,35patientsinthetreatmentgroupand33patientsinthecontrolgroup.Attheendof2weeks,lpatientinthetreatmentgroupobtainedanexcellentresult,27goodand7bad;inthecontrolgroup,
8、2pati