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1、急性冠脉综合征患者血清炎性指标及肌钙蛋白I的临床研究【摘要】 目的 研究急性冠脉综合征患者(ACS)血清炎性指标的水平与肌钙蛋白I的关系及临床意义。方法 测定冠脉造影阳性的ACS患者74例、稳定型心绞痛(SAP)患者58例和造影阴性的冠心病患者46例(对照组)血清超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、可溶性P-选择素(sP-sel)和肌钙蛋白I(cTnI)的水平,并采集相应的各项临床资料。结果 ACS组患者血清各项炎性指标分别为hs-CRP(7.40±2.90)mg/L、IL-6(235.62±87.03)ng/L、sP-sel(87.82±3
2、6.02)mg/L、cTnI(4.38±3.85)mg/L,高于SAP组患者和对照组,差异均有统计学意义(t分别=6.52、4.94、2.97、7.23、8.96、5.63、3.32、8.67,P均<0.05);cTnI增高患者各血清炎性指标分别为hs-CRP(8.74±1.61)mg/L、IL-6(265.33±66.62)ng/L、sP-sel(99.43±25.42)mg/L,明显高于cTnI正常者,差异均有统计学意义(t分别=4.59、3.92、3.65,P均<0.05)。结论 血清炎性指标在ACS患者中均表现为增高。cTnI与血清各项炎性指标具有相关性。c
3、TnI及血清各项炎性指标与冠脉内斑块的不稳定状态具有相关性。【关键词】急性冠脉综合征炎性指标肌钙蛋白I ClinicalresearchonserumlevelsofinflammatoryindicatorsandcardialtroponinIinpatientswithacute10coronarysyndromeLINJianping,WUGuohua.CenterofClinicalLaboratory,WuyiFirstPeople'sHospital,Wuyi321200,China AbstractObjectiveToexplorerelati
4、onshipandclinicalsignificanceofserumlevelsofinflammatoryindicatorsandcardialtroponinIinpatientswithacutecoronarysyndrome(ACS).MethodsSerumlevelsofhighsensitivityCreactiveprotein(hs-CRP),interleukin-6(IL-6),solubilityP-selectin(sP-sel),cardialtroponinI(cTnI)in74casesofpositivecoronaryvi
5、sualizationpatientswithACS,58casesofpatientswithstableanginapectoris(SAP)and46casesofnegativecoronaryvisualizationpatientswithcoronaryheartdisease(CHD)(controlgroup)weredetermined.Relatedclinicaldataofthesepatientswereanalyzed.ResultsTheserumlevelsofinflammatoryindicatorsofpositivecTnI
6、patientswerehs-CRP(8.74±1.61)mg/L;IL-6(265.33±66.62)ng/L;sP-sel(99.43±25.42)mg/L.AndthoseofACSgroupwerehs-CRP(7.40±2.90)mg/L;IL-6(235.62±87.03)ng/L;sP-sel(87.82±36.02)mg/L;cTnI(4.38±3.85)mg/L.TheserumlevelsofeachinflammatoryindicatorsofpatientsinACSgroupweresignificantlyhigherthanthato
7、fpatientsinSAPgroupand10controlgroup(t=6.52,4.94,2.97,7.23,8.96,5.63,3.32,8.67,P<0.05).TheserumlevelsofeachofinflammatoryindicatorsofpositivecTnIpatientswassignificantlyhigherthanthatofnegativecTnIpatients(t=4.59,3.92,3.65,P<0.05).ConclusionsTheserumlevelsofeachofinflammatoryin