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1、126例儿童过敏性疾病血清总IgE含量及特异性过敏原检测分析??_——478._.——文章编号:1007—4287(2011)03—0478—04ChinJLabDiagn,March,20l1,V0115,No.3126例儿童过敏性疾病血清总IgE含量及特异性过敏原检测分析戴海玲,苏屿,韩景辉,符生苗(海南省人民医院检验科,海南海口570311)摘要:目的分析患有过敏性疾病儿童血清中总IgE含量和主要过敏原种类.方法采用德国欧蒙印迹法检测126例儿童过敏性疾病患者血清中特异性IgE种类,采用美国贝克曼化学发光仪D
2、XI800检测血清中总IgE含量.结果126例儿童过敏性疾病患者总IgE阳性率为81.0%,特异性过敏原阳性率为74.6%.吸入组最高为屋尘52例,其次为屋尘螨/粉尘螨47例;食人组最高为虾23例,其次为其次为鸡蛋白,蟹,牛奶.结论儿童过敏性疾病患儿血清中总IgE含量明显升高,吸入性过敏原以屋尘为主,食入性过敏原以虾为主.说明大多数患者被多种过敏原致敏.通过对血清总IgE水平的测定评估过敏性疾病及过敏性体质的重要指标,再通过特异性过敏原的测定,可了解引起患儿过敏的过敏原,寻找病因,尽量避免接触此类过敏原,减少发病.
3、关键词:总IgE;特异性过敏原;过敏性疾病中图分类号:R392文献标识码:A126casesofchildrenthallergicdiseasesandthespecificityoftotalserumIgEleve~ofallergendetectionDMHat-ling,SUYu,HANJing-hui,et.(HainanProvincialPeople'sHo~italLaboratory.Haikou5703l1,China)Abstract:ObjectiveAnalysisofchildrenw
4、ithallergicdiseasesSelMmtotalIgElevelsandthemaintypesofallergens.MethodsGermany,EuropeandMongoliablotusing126patientswithallergicdiseasesofchildreninspecific.serul~IgEtype,llsingtheU.S.BeckmanchemiluminescenceDXI800sertl/TllevelsoftotalIgE.Results126patientswi
5、thallergicdiseasesofchildrenpositiverateWaS81.0%oftotalIgE.specificallergens.thepositiverateWaS74.6%.Housedustinhalationwasthehighestforthe52casesfol—lowedbyhousedustmites/dustmitesin47cases;foodgroupwasthehighestfortheshrimpintothe23casesfoHowedbyfotowedbyegg
6、white,crab,milk.ConclusionsenⅡnofchildrenallergicdiseasesweresignificantlyhighertotalIgE,inhalantallergensinhousedustwasthemainfoodallergensinshrimp-based.Notethatmostpatientswereallergictomultipleallergensallergens.Throughthede—terminationofSelqm3totalIgEleve
7、lassessmentofallergicdiseasesandanimportantindicatorofallergicconstitution,andthenmea—suredbyspecificallergens,carlunde~tandthecauseofallergensinchildrenwithallergiestofindthecause,trytoavoidcontactwiththeseallergens,reducetheincidence.Keywords:TotalIgE;Specif
8、icallergens;Allergicdiseases过敏性疾病人群发生率很高,是临床常见多发病,但往往因为缺乏明确的病因,给预防和治疗造成困难,致使病情反复,迁延不愈.以前我院采用的体内试验是将少量过敏原通过皮内注射或点刺等方法注入体内,观察皮肤反应.该方法敏感,快速,但儿童很难配合,家长难于接受,有时会因皮肤反应性过高和过敏原之间的交叉反应性而出现假阳
