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1、154例儿童无色素性痣临床分析$36ORIGINALARTICLEJournalofClinicalrmatology2003:32(SupplementClinicalFeaturesofNevusDepigmentosusin154ChildrenHuanXing,Li—bingFuDepartmentofdermatology,BeijingChildrenHospital,Beijing,100045,PR.ChhTa*Departmentofpathology,BeijingChild
2、renHospital,Beijing,100045,PR.ChinaSummaryObjectiveToinvestigatetheclinicalandhistopathologiccharacteristicsofnevusdepigmentosusinchil—drenandanalyzethedifferencesbetweennevusdepigmentosusandotherlocalizedleukodermassoastoen—abletheclinicianstomakeam
3、oreaccuratediagnosis.MethodsAclinicalsurveywasdonein154childrenwithnevusdepigmentosus.Skinbiopsyspecimensweretakenfrom14children.Thesectionswerestainedwithhematoxylin—eosinandHMB45antibodywithimmunohistochemistryassay.ResultsThelesionsweremostlyprese
4、ntbeforelyearofage(83.8%).Thetrunkwasthemostcommonlyaffectedsitef42.2%).Ofthel54patients,isolatedtypewasfoundin96cases(62.3%),followedbysegmen—taltypein55cases(35.7%)andwhorledorsystematizedtypein3cases(1.9%).Ninety—sixpatients(62.3%)hadirregularbord
5、er,someofwhichwereserratedorsplashed.Histopathologicstudyshowedthattherewerenoobviouschangesinthenumbersofmelanocytesinthebasallayer.ConclusionsTheclinicalandhistopathologiccharacteristicsofnevusdepigmentosusaredifferentfromotherleukodermas.NKeywords
6、:nevus,depigmentosus(achromicnevus),melanocyte,childrenevusdepigmentosusorachromicnevusisdefinedasacongenitalnonprogressivehypopigmentedmaculethatisstableinitsrelativesizeanddistri—bution.Thefirstreportwasmadein1884byLesser.Theclinicaldiagnosticcrite
7、riawidelyusedfornevusdepigmen—tosuswasproposedbyCoupein1967.1.Unilaterallackofpigmentinasystemizeddistribution2.Presencesincebirth.oronsetearlyinlife3.Noalterationindistributionofthenon—pigmentedareasthroughoutlife4.Noalterationintexture,orchangeofse
8、nsationoftheaffectedarea5.NohyperpigmentedborderaroundtheachromicareaNevusdepigmentosus(ND)isnotararedisease,thereare.however.veryfewcasereportsinChina.NDiseasi—lyconfusedwithotherlocalizedhypopigmenteddiseases.Theleaf-shapedhypopigmentedmaculeoftube
