老年黄斑变性43例光学相干断层扫描分析.doc

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1、老年黄斑变性43例光学相干断层扫描分析【摘要】　　目的：研究老年黄斑变性的光学相干断层扫描（opticalcoherencetomography，OCT）特征。方法：对经眼底荧光造影（fundusfluoresceinangiography，FFA）确诊的老年黄斑变性患者43例45眼，其中湿性型28例30眼、干性型15例15眼，按年龄匹配的正常人30例43眼利用OCT分别进行检测。观察黄斑部神经纤维层（nervefiberlayerofmacular，MNFL）、色素上皮/脉络膜毛细血管复合层(retinalpigmentepithelium/choriocapillaris,RP

2、E/CC)及视网膜神经上皮层(retinalneurepitheliumlayer，RNE)的厚度变化。应用秩和检验比较其差异性。结果：MNFL厚度：湿性型老年黄斑变性组为76.5±51.7μm、干性型老年黄斑变性组为32.5±7.6μm、正常对照组为27.7±6.4μm，湿性型组与其他组比较差异有显著性(P﹤0.05)。RNE厚度：湿性型老年黄斑变性组为307.1±130.8μm、正常对照组为239.9±13.4μm、干性型老年黄斑变性组为223.4±22.6μm，湿性型组与其他组比较差异有显著性(P﹤0.05)。RPE/CC厚度：湿性型老年黄斑变性组为115.3±30.6μm、

3、干性型老年黄斑变性组为81.7±20.4μm、正常对照组为76.4±11.5μm，湿性型组与其他组比较差异有显著性(P﹤0.05)。结论：黄斑部神经纤维层厚度、视网膜神经上皮层厚度及色素上皮/脉络膜毛细血管复合层厚度随着老年黄斑变性病程的发展，其厚度增加。OCT可以作为湿性型老年黄斑变性发生与发展的监测工具之一。【关键词】光学相干断层扫描　老年黄斑变性　　　Opticalcoherencetomographyonage-relatedmaculardegenerationAbstractAIM:Toobservethefeaturesofage-relatedmaculardege

4、neration(ARMD)ontheopticalcoherencetomography(OCT).METHODS:OCTwasusedtomeasurethehealthyvolunteers(30people,43normaleyes)andpatientswithage-relatedmaculardegeneration(43people,45eyes)thatweredividedintowettypegroup(28person30eyes)anddrytypegroup(15person15eyes)werediagnosedbyfundusfluoresceina

5、ngiography(FFA).Thedifferencesamongthenormalgroupandtheage-relatedmaculardegenerationgroupswerecompared.StatisticalanalysiswasperformedbySPSSversion12.0underwindowssystemtocomparethenervefiberthicknessofmacular(MNFL),neurepitheliumlayerthickness(RNE)andretinalpigmentepithelium/choriocapillaris

6、(RPE/CC).RESULTS:1.ThethicknessofMNFL:76.49±51.72μminwettypegroup,32.45±7.59μmindrytypegroup,and27.71±6.40μminnormalgroup.Thedifferencebetweenthewettypegroupandothergroupshadstatisticallysignificant(P﹤0.05).2.ThethicknessofRNE:307.12±130.81μminwettypegroup,239.90±13.39μminnormalgroup,and223.38

7、±22.64μmindrytypegroup.Thedifferencebetweenthewettype6groupandothergroupshadstatisticallysignificant(P﹤0.05).3.ThethicknessofRPE/CC:115.33±30.62μminwettypegroup,81.67±20.41μmindrytypegroup,and76.38±11.48μminnormalgroupwas.Thedifferenceb