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1、VEGF和PEDF在实验性大鼠角膜新生血管组织中的动态表达眼科新进展2006年8月第26卷第8期RecAdvOphthalmolVo1.26No.8August2006?573?作者简介:孙京华,女,1949年8月出生,上海人,副教授.联系电话:027—83663333,13317198997;E—mail:zhangyuzhao~126.comAhoatSUNJing-Hua:F~-nale,bominjBt,1949.A.,~ciateprofessor.Tel:+86—27—83663333,1331
2、7198—997;E-mail:zhangyuzha~126.coHq收稿日期:20o5—10—27修回日期:2006—02—16本文编辑:周志新作者单位:430030湖北省武汉市,华中科技大学同济医学院附属同济医院眼科Receiveddate:Oct27,2005Accepteddate:Feb16,2006FtomtheDepartmentofOphthal—mology,TongiiHospitalAffiliat—edtoTongjiMedicalCollege,HuazhongUniversity
3、ofScienceandTechnology,Wuhan430030,Hube/Prov/nce,ChinaVEGF和PEDF在实验性大鼠角膜新生血管组织中的动态表达孙京华张煜昭王慧王净信刘常明DynamicexpressionofVEGFandPEDFinex.perimentalratcornealneovascularizationtis.SUeSSUNJing—Hua,ZHANGYu-Zhao,WANGHui,WANGJin9-Xin,LIUChang-Ming【Keywordslvasculare
4、ndothelialgrowthfactor;pigmentepitheliumderivedfactor;alkaliburn;cornealneovascularization【Abstract】ObjectiveTosttidythedy.amlcexpressionsandeffectsofvas--cularendothelialgrowthfactor(VEGF)andpigmentepitheliumderivedfac-tor(PEDF)inthedevelopmentofexperimen
5、talratcornealneovascularization(CNW).MethodsRatcornealalkalineburnmodelwasestablishedbyroutinemethod.ImmunereactionsofVEGFandPEDFweredetectedonthe1st,3rd,5th,7th,10thand14thdayrespectivelyaftertheburn,andtheproteinexPres-sionsweremeasuredbyimage-analysissy
6、stem.Resul协InCNVtissues.thepositiveinlnlunereactionofVEGFwasmostapparentduringthe3rd～7thdayandthendeclinedremarkablyonthe14thday.Certaintime-correlationexistedbetweenthedynamicexPressionsofVEGFandPEDFandthedevelopmentofCNW.ConclusionTheexpresslonsofVEGFand
7、PEDFareremarkablyex-pressedinexperimentalratCNVtissues,andthefluctuateofwhichisconsis-tentwiththedevelopmentofCNVebreakdownofthebalancebetweenthetwofactorsmayPlaYaroleinCNVoccurrenceanddevelopment.IRecAdvOphthalmol2006;26(8):573-576J【中图分类号】Q959.836;R772【文献
8、标识码】A【文章编号】1003—5141I2006)08—0573-04【关键词】血管内皮生长因子;色素上皮衍生因子;碱烧伤;角膜新生血管【摘要】目的探讨血管内皮生长因子vascularendothelialgrowthfactor,VEGF)和色素上皮衍生因子(pigmentepitheliumderivedfactor,PEDF)在实验性大鼠角膜新生血管(com~lneovascularization,CNV
