三种软骨保护剂在关节开放性手术中对兔关节软骨中蛋白多糖含量的影响

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1、万方数据中国组织工程研究与临床康复第，3誊勇争2期’2009—01—08出版JournalofClinicalRehabilitativeTissueEngineeringResearchJanuary82009VoL13,No．2三种软骨保护剂在关节开放性手术中对兔关节软骨中蛋白多糖含量的影响★殷胜春EffectofthreekindsofprotectantsonproteoglycancontentsinrabbitarthrodlalcartilagearthrotomyYinSheng—chunFiratDepadmentofOrtho

2、paedics．Workers'HospitalofTangshan，Tangshan063000．HebelProvince，ChinaYinSheng·chun★．Master,Attendingphysician．同r8tDepartmentofO胁opaedics．Workers’HospitalofTangshan．Tangshan063000．HebeIProvince．China7093977350qq，cornReceived：2008-07-24Accepted：2(X)8-Oe-06唐山工人医院骨1科，河北省唐山市063000

3、殷胜春★，男，1973年生，河北省玉田县人，2008年河北医科大学关节骨科毕业，硕士，主治医师，主要从事创伤骨科、关节骨科研究．709397735@qq．com中图分类导：R钓1．3文献标识码：B文章编号：1673-8225(2009)02-00276-04AbstractBACKGROUND：Mostofosteoarticu-larinjudesneedsurgicaltreatment，inwhichcausefurtherdamagetoarticularcanilagebyexposedtoairanddrying．itisnecess

4、arytotakesomeprotectivemeasuresinsurgery．OBJECTIVE：Toinvestigatetheeffectofthreekindsofprotectantsincludingsodiumchloride，50g，LmannitoIandsodiumhyaluronateonproteoglycancontentinrabbitarthrodiaIcartilagearthrotomy．DESlGN．TIMEANDSETTlNG：TherandomizedcontroIanimaIexpenmentwasco

5、mpletedintheCentralLabOratoryofWorkers。HospitalofTangshanfromOctobertoDecemberin2007．MATERIALS：Sixty-fivefemaleNewZealandwhiterabbitswith4一month-old．weighting2．5—3．0kgweredividedintotheexpenmentgroup(n=-60)andthecontrolgroup(n=-5)byrandomnumbertable．111eexperimentgroupwerediv

6、idedinto5subgroupswith15rabbitsineachaccordingtotreatedwithsodiumchloride．509／Lmannitol，sodiumhyaluronateandunprotected，respectively．METHODS：Thekneejointsofrabbitsintheexperimentgroupwereexposedtoairwiththe22℃and65％humidity，articularcartilageoffemoralmedialcondylewasdamagedby

7、quantitativestrikeassemblytocreatelow·energydamagedmodels．Rabbitsjntheprotectiongroupweremoistedbysodiumchloride，50g，Lmannitol，andsodiumhyaluronate，respectively．Therewerenotreatmeritintheunprotectiongroup．At2hours，1。2，4，8weekendpostoperative。3rabbitsineveryexperimentgroupand1

8、rabbitintwocontroIgroupswereselectedandtookarticularcartilageoffemor